Project Grant R01AR086121
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Delaware a $666,825 Project Grant on September 1, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the structural and functional roles of muscle-subtendon units in Achilles tendinopathy. The research will extend through June 30, 2030, utilizing advanced biomechanical sensors, magnetic resonance imaging...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Pennsylvania a $546,145 Project Grant effective May 1, 2026, through March 31, 2031, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project, titled "Molecular Mechanisms of Telomere Function in Muscle Cells," will deliver fundamental scientific research and discovery outputs focused on...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Regents of the University of Colorado a $348,339 project grant (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research) effective May 1, 2026, through April 30, 2028, to conduct research on the modulation of tendon mechanics by hyaluronic acid (HA). The research addresses the critical need to understand how deviations in glycosaminoglycan content affect...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded New Jersey Institute of Technology a $330,107 Project Grant effective September 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports fundamental research investigating the role of stress anisotropy—directional stress differences in extracellular matrices—in fibroblast activation and its...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The University of Pennsylvania a $719,758 Project Grant effective July 10, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research investigating the role of nuclear myotubularin (MTM1) in muscle development and the pathogenesis of X-linked myotubular myopathy (XLMTM), a devastating...
- Federal Project Grant Award Summary Massachusetts General Hospital has received a $243,192 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) effective November 1, 2025, with completion targeted for April 30, 2028. The project, "Investigating the Role of Wnt Signaling in the Mechanical Maturation of Tendon," will deliver research services...
- Federal Grant Award Summary The University of Pennsylvania received a $646,506 Project Grant award dated September 5, 2025, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This grant supports the development of dual-action nanoparticle-loaded microparticles designed to treat osteoarthritis (OA) through a novel combination therapeutic approach. The research delivers...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $100,228 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective November 16, 2026, with a completion date of May 31, 2029. The award funds basic science research investigating mechanosensation in muscle-resident mesenchymal stromal cells, specifically...
- Federal Grant Award Summary The University of Oregon received a $1,958,125 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 15, 2025, through August 31, 2028. The project, titled "Orchestrating Tendon Regeneration through Nanoparticle Drug Delivery," develops an innovative targeted drug delivery platform to improve tendon...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a Project Grant totaling $671,214 beginning June 1, 2026, with a completion date of March 31, 2031, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This research project investigates the role of somatosensory nerves in fracture repair, specifically examining how Nerve Growth Factor (NGF) and Fibroblast...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The University of Pennsylvania a $507,606 Project Grant (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research) effective June 1, 2026, through March 31, 2031. This award funds research investigating the mechanotransductive mechanisms by which mechanical loading influences tendon cell behavior through focal adhesion kinase (FAK) signaling. The project deliverables include basic science research examining how mechanical cues are transmitted from the extracellular matrix to tendon cell nuclei, utilizing both ex vivo tendon loading experiments and genetically modified mouse models with FAK knockdown in tendon tissue. The research will generate peer-reviewed publications, mechanistic data on cytoskeletal tension regulation in tendon homeostasis, and preclinical animal model findings that elucidate the role of FAK phosphorylation in mediating cellular responses to mechanical stimuli. These outputs will advance the mechanistic understanding of tendon disease pathogenesis and inform future therapeutic development strategies for tendon injuries and musculoskeletal disorders, directly supporting NIAMS's mission to advance knowledge of musculoskeletal disease causes and treatments.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $507.6k | 5/28/26 |