Project Grant R01AR084243
- This $249,000 project grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the epigenetic regulation of the extracellular matrix and virus-induced fibroblast activation. The research project, which will be conducted at Tufts University over a 3-year period from September 15, 2025 to September 14, 2028, seeks to advance the understanding of the molecular mechanisms...
- This Project Grant award, totaling $176,148.00 and effective from April 1, 2025 to March 31, 2030, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The funding supports a research project led by Dr. Maxime Kinet at the University of California, San Francisco (UCSF) that aims to elucidate the mechanisms by which PI16-expressing fibroblasts, a...
- This Project Grant award, valued at $451,000.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to determine the physiological nutrients and metabolic pathways required for fibroblast extracellular matrix (ECM) synthesis during tissue repair. The research program, to be conducted at the University of Chicago from September 1, 2025 to August 31, 2030, aims to address the central...
- This $629,998 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support Worcester Polytechnic Institute's research to investigate biophysical and biochemical drivers of fibrosis progression and regression across engineered in vitro platforms for the pancreas, skin, and uterine fibroids. The goal is to develop advanced in vitro models that enable control over tissue-specific extracellular matrix features, cellular composition, and exogenous...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. to conduct research on the role of Notch signaling and fibrosis in treatment-resistant rheumatoid arthritis. The project aims to define the molecular mechanisms by which Notch signaling regulates transforming growth factor beta (TGF-β) signaling in...
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $413,655 on August 1, 2025 to Arizona State University (ASU) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop biomaterials with temporal control of proteins, such as Bone Morphogenetic Proteins (BMPs), to enhance bone repair. The research aims to mimic natural extracellular matrix interactions and synergies...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $2,070,827 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Icahn School of Medicine at Mount Sinai. This grant aims to identify novel microbial factors that can enhance wound repair, a significant public health issue with over 100 million new acute skin wounds annually and substantial treatment costs exceeding $25 billion. The...
- This National Science Foundation (NSF) CAREER award under the Engineering program (CFDA 47.041) provides $624,622 over 5 years starting September 1, 2025 to support research aimed at advancing the scientific understanding of cartilage microstructure and function. The principal investigator will leverage quantitative magnetic resonance imaging (MRI) techniques to study how changes in the microscopic structure of cartilage impact its macroscopic behavior under loading conditions experienced in...
- The University of Southern California (USC) received a $628,174 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this multi-year grant, with an ultimate completion date of March 31, 2030, is to support research into the cellular origins and molecular mechanisms underlying the development of arthrofibrosis, a debilitating...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the role of stress anisotropy in fibroblast activation. The $330,107 award to the New Jersey Institute of Technology (NJIT) aims to: Explore strategies for controlling long-term fibroblast activation by reducing stress anisotropy, using advanced micropatterning technology to manipulate extracellular matrix (ECM) stiffness, cell shape, cell area, and the magnitude and direction of stretching. This will test whether reducing stress field anisotropy can prevent prolonged fibroblast activation in clinical settings like skin grafting. Investigate the interplay of extracellular and intracellular factors in fibroblast responses to anisotropic stress fields, hypothesizing that changes to ECM properties due to aging or diseases like fibrosis affect mechanical signal transmission and impact fibroblast activation. This research builds on NJIT's recent discoveries showing that stress anisotropy significantly impacts fibroblast activation and can induce cellular mechanical memory. The grant award period runs from September 1, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $330.1k | 8/22/25 |