Project Grant R01AR084310

Award Date 7/10/25
Completion Date 6/30/30
Dollars Obligated $720K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $439,791.00 over a 5-year period from March 1, 2025 to February 28, 2030 to The University of Texas Southwestern Medical Center. The funding will support research to investigate the molecular mechanisms underlying myoblast fusion, which is essential for skeletal muscle development and...
This Project Grant award of $488,575 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to understand how myosin binding protein-C (MyBP-C) regulates skeletal muscle contraction and the effects of mutations in genes encoding slow and fast MyBP-C paralogs. The University of Arizona, serving as the prime awardee, will use a novel "cut and paste"...
This federal Project Grant award of $201,960 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to define the functional roles of different isoforms of the myosin-binding protein C (MyBP-C) in skeletal muscle. The University of Vermont & State Agricultural College, the grant recipient, will use the "designer MyBP-C" zebrafish model system...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the novel role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective March 14, 2025 through February 28, 2030, will be used by the University of Wisconsin-Madison to interrogate the potential of...
This Project Grant award of $1,222,648.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The award will fund research by Cornell University over a 5-year period starting on Sep 1, 2024 to identify the mechanism responsible for "ultra-rapid" induction of mechanoresponsive genes and determine the functional consequences of impaired...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research on the role of mitochondrial respiration and bioenergetic metabolism in the development and differentiation of growth plate chondrocytes. The $459,820 award to The Trustees of the University of Pennsylvania, Clinical Practices of the University of Pennsylvania, will fund a...
This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the functional roles of microRNA-320 (miR-320) in skeletal muscle. The $374,204 award to The Leland Stanford Junior University will fully characterize a muscle-specific miR-320 knockout mouse model, examine the underlying mechanisms of the observed muscle wasting...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop specialized cryo-electron microscopy (cryo-EM) techniques to study the structures of mitochondrial complexes implicated in muscular myopathies. The $444,109 award to the Scripps Research Institute in La Jolla, CA will support the creation of methods to directly visualize endogenous...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research into the role of the nuclear protein myotubularin (MTM1) in muscle development and the pathogenesis of X-linked myotubular myopathy (XLMTM). The $719,758 award to the University of Pennsylvania will fund a 5-year study to characterize the localization and interactome of nuclear MTM1, define alterations in nuclear structure and genome organization associated with MTM1 mutation, and test the impact of nuclear versus non-nuclear MTM1 during muscle development. The research aims to advance understanding of the contribution of nuclear abnormalities to XLMTM disease pathogenesis and lay the groundwork for future therapy development.

Generated 8/5/25, 5:02 AM