Project Grant R01AR085951
- This $360,580 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop an engineered extracellular matrix (EECM) that can promote regenerative healing in tendons. The University of Oregon will fabricate anisotropic PEG hydrogel-based EECM scaffolds and evaluate their ability to guide the alignment and matrix deposition of human...
- This $499,229 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the mechanisms underlying adult tendon regeneration in the zebrafish model. The research aims to examine the relationship between TGFβ signaling and muscle activity in tendon regeneration, including investigating how reduced TGFβ signaling and muscle...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to advance the understanding of muscle-subtendon units and their role in Achilles tendinopathy. The $666,825 award to the University of Delaware will fund a 5-year research study using advanced in vivo techniques such as MRI, ultrasound, and biomechanical assessments. The key objectives are...
- This federal Project Grant award of $646,506 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of dual-action nanoparticle-loaded microparticles for the treatment of osteoarthritis (OA). The research aims to create innovative nanoparticle-based therapeutics that can stimulate the anabolic activity of chondroprogenitors to enhance cartilage...
- The National Science Foundation awarded a $750,000 Project Grant to Rutgers, The State University under the Engineering program (CFDA 47.041) from September 1, 2022 to August 31, 2025. The grant funds research to develop an injectable nanoparticle therapy to restore strength and length to damaged tendons and ligaments. Specifically, the university will investigate combining a thermosensitive polymer and crosslinking agent to stabilize joints by quickly strengthening and returning tissues like...
- The University of Rochester was awarded a $464,315 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year project, beginning on July 1, 2025, is to investigate the role of the L-type Ca2+ channel Cav1.2 in the development of Achilles tendinopathy. The research aims to identify early mediators in tendons in response to...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $158,912 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), with a project period from November 1, 2025 to April 30, 2028. The goal of this research project is to elucidate the role of Wnt signaling in the mechanical maturation of tendon, which is...
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- The University of Oregon received a $886,403 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research program) on September 15, 2025. The award supports the development of a nanoparticle-based therapeutic to accelerate fracture healing in aging populations. The nanoparticles are designed to target fracture sites and deliver a Wnt/β-catenin pathway agonist, providing a dual benefit of targeted delivery and therapeutic modulation. Preliminary data indicates...
- This federal Project Grant award of $306,722 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funding supports Penderia Technologies Inc., a small business joint venture located in Eugene, Oregon, to fabricate and characterize a distal femoral fracture fixation plate that features an implantable, battery-free, wireless sensor. This sensor will enable...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is providing $1,958,125.00 to the University of Oregon to develop an innovative nanoparticle drug delivery system to improve tendon regeneration following acute injuries. The researchers aim to leverage a novel peptide that specifically targets and binds to inflammation markers in healing tendons, allowing the nanoparticle system to efficiently deliver therapeutic payloads to the injury site. This multifaceted research effort spans optimizing the targeting capabilities, evaluating efficacy in adult and aged tendon healing models, and establishing the cellular mechanisms through which the nanoparticle system can enhance tendon regeneration. By advancing this platform technology, the project seeks to address the unmet clinical need for effective pharmacological interventions to improve functional recovery after common tendon injuries.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/15/25 |