Project Grant R01AR087383
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a $543,417 Project Grant effective June 1, 2026 through May 31, 2031, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research initiative focuses on promoting functional neuromuscular regeneration following chronic volumetric muscle loss (VML) in aged mice. The project will deliver three primary...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a Project Grant of $176,040, effective September 1, 2025, through August 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This research project addresses critical diagnostic and genetic gaps in cystic fibrosis (CF)-related osteoporosis by identifying genetic modifiers and developing improved...
- Federal Project Grant Award Summary This Project Grant, awarded July 15, 2025, by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $169,344 in federal funding to the University of California, Davis through June 30, 2030. The award supports mechanistic research investigating systemic and local immunomodulation of fracture healing in polytrauma patients, addressing a...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Johns Hopkins University a $521,362 Project Grant on August 12, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neuroimmune interactions in craniofacial bone healing. The research project, which extends through August 11, 2027, seeks to decode the signaling mechanisms between nerves, immune cells, and bone-forming cells during cranial bone repair....
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded New Jersey Institute of Technology a $330,107 Project Grant effective September 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports fundamental research investigating the role of stress anisotropy—directional stress differences in extracellular matrices—in fibroblast activation and its...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a Project Grant (R21) totaling $232,938 on February 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports fundamental neuroscience research investigating neuronal membrane proteasome-derived peptide (NMP-peptide) signaling mechanisms in the peripheral nervous system, with...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $372,171 Project Grant to The Research Foundation for the State University of New York (RF SUNY), effective June 1, 2026, through May 31, 2028, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research into the mechanistic investigation of galectin-3 (GAL3)-expressing macrophages in fracture callus fibrosis and...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The University of Pennsylvania a $507,606 Project Grant (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research) effective June 1, 2026, through March 31, 2031. This award funds research investigating the mechanotransductive mechanisms by which mechanical loading influences tendon cell behavior through focal adhesion kinase (FAK) signaling. The project deliverables...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded President and Fellows of Harvard College a $676,841 project grant effective August 1, 2025, through July 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project, "Leveraging Human Musculoskeletal Development to Identify Causal Disease Variants," will deliver comprehensive transcriptomic and epigenomic mapping of human...
- Federal Cooperative Agreement Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a Cooperative Agreement totaling $267,527 (awarded September 10, 2025, with completion by August 31, 2026) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds a clinical research study investigating optimal timing of flap coverage surgery in the treatment of severe lower extremity...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a Project Grant totaling $671,214 beginning June 1, 2026, with a completion date of March 31, 2031, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This research project investigates the role of somatosensory nerves in fracture repair, specifically examining how Nerve Growth Factor (NGF) and Fibroblast Growth Factor 9 (FGF9) signaling mediate nerve-bone interactions during healing. The research utilizes advanced methodologies including retrograde peripheral nerve tracing and single-cell RNA sequencing to characterize the transcriptomic profile of bone-innervating sensory neurons and their dynamic response to traumatic bone injury. The primary deliverables include mechanistic research findings on sensory neuron-derived FGF9 signaling in fracture repair, with planned experiments utilizing peripheral neuron-specific FGF9 deletion models and rescue experiments involving recombinant FGF9 application. Research outcomes will advance understanding of nerve-bone crosstalk and generate preclinical data supporting potential therapeutic interventions to enhance fracture healing. Expected products include peer-reviewed publications, animal model data, and mechanistic insights applicable to the development of novel therapeutic approaches for musculoskeletal repair.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $671.2k | 6/3/26 |