Project Grant R01AR085639
- The University of Rochester was awarded a $464,315 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year project, beginning on July 1, 2025, is to investigate the role of the L-type Ca2+ channel Cav1.2 in the development of Achilles tendinopathy. The research aims to identify early mediators in tendons in response to...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is providing $1,958,125.00 to the University of Oregon to develop an innovative nanoparticle drug delivery system to improve tendon regeneration following acute injuries. The researchers aim to leverage a novel peptide that specifically targets and binds to inflammation markers in healing...
- This $360,580 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop an engineered extracellular matrix (EECM) that can promote regenerative healing in tendons. The University of Oregon will fabricate anisotropic PEG hydrogel-based EECM scaffolds and evaluate their ability to guide the alignment and matrix deposition of human...
- This $499,229 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the mechanisms underlying adult tendon regeneration in the zebrafish model. The research aims to examine the relationship between TGFβ signaling and muscle activity in tendon regeneration, including investigating how reduced TGFβ signaling and muscle...
- This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $158,912 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), with a project period from November 1, 2025 to April 30, 2028. The goal of this research project is to elucidate the role of Wnt signaling in the mechanical maturation of tendon, which is...
- This Project Grant award, valued at $359,133.00, was issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports the generation of new genetic tools to enable more targeted and specific analysis of tendon and musculoskeletal tissues in mice. The goal is to develop constitutive and inducible FLP alleles that can be used in combination with existing...
- This $546,159 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Federal Grant Program (CFDA 93.846) will support a cross-sectional observational study on the relationship between foot biomechanics, metatarsal structure, and running footwear in athletes with bone stress injuries. The study will evaluate associations between foot biomechanics, intrinsic foot muscle size and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $198,263 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Board of Regents of the University of Nebraska. The research project aims to investigate the role of the protein Mitsugumin 53 (MG53) in preventing muscle atrophy during periods of disuse, which can contribute to age-related sarcopenia and frailty. The research will explore how...
- The University of Delaware was awarded a $601,120 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year study is to validate next-generation methods for diagnosing and predicting bone fracture healing, using an ovine (sheep) tibial osteotomy model. The research will employ ultrashort echo time magnetic resonance imaging...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to advance the understanding of muscle-subtendon units and their role in Achilles tendinopathy. The $666,825 award to the University of Delaware will fund a 5-year research study using advanced in vivo techniques such as MRI, ultrasound, and biomechanical assessments. The key objectives are to analyze how different muscle-subtendon units in the Achilles tendon respond to standard exercise treatments for tendinopathy, and to develop diagnostic and therapeutic strategies tailored to the individual structures of these muscle-subtendon units. The findings from this research could lead to improved treatment options for this prevalent and debilitating condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $666.8k | 8/25/25 |