The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,685,326 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant supports research to examine the role of CD101 in immune suppression, characterize functional responses of CD101-high neutrophils, investigate the mechanisms for Wnt5 to regulate splenic extramedullar hematopoiesis, and determine the transcription factors that control the molecular and...
This federal Project Grant award of $837,497 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Yale University focused on understanding the role of the PI3K-gamma protein in regulating antibody responses. The funded project aims to define the molecular mechanisms by which PI3K-gamma signaling in B cells promotes the differentiation of antibody-secreting cells, a key process for generating protective...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $242,310 to Yale University to conduct research aimed at elucidating the cellular and molecular mechanisms governing the catabolism (breakdown) of immunoglobulin E (IgE). The research project seeks to uncover the receptors and cell types responsible for IgE clearance, as well as the impact of IgE glycosylation on its...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award of $1,310,631.89, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports the development and optimization of antibody-targeted nanoparticle delivery systems to selectively target endothelial cells in human organ allografts. The goal is to prevent the expression of surface proteins that contribute to T cell-mediated rejection and improve long-term graft outcomes, thereby reducing the...
This $531,245 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research by Yale University to structurally and functionally characterize the sorting platform component of the type III secretion system (T3SS) in Salmonella bacteria. Through a multidisciplinary approach involving bacterial genetics, biochemistry, microscopy, and cryo-electron microscopy, the research aims to...
This Project Grant award of $3,262,539.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research by Yale University to elucidate the molecular mechanisms underlying the assembly of the mycobacterial cell envelope, a critical barrier to antibiotics and important target for drug development. The key research aims include investigating the cytoplasmic synthesis and transport of mycolic acids, defining the physiological...
This $4,908,988 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant supports research to investigate the mechanisms by which gut microbiota and white adipose tissue control the CD4 T-cell compartment and facilitate the trafficking of these immune cells from the gut to the brain. The research aims to elucidate the gut-brain axis and its role in...
This $737,502 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the WDFY4 protein in regulating antigen presentation by dendritic cells for the development and maintenance of regulatory T cells (Tregs). The overarching goal is to better understand the immune mechanisms underlying coordinated antigen presentation, which could lead to...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...