This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved...
This federal Project Grant award of $451,292.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to uncover neuronal mechanisms that orchestrate metabolic adaptations to bacterial infections, with a focus on delineating the role of the brain-liver axis in modulating metabolic responses. The research seeks to identify neurocircuits in the hypothalamus that monitor circulating lipoproteins and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
This Project Grant award, valued at $242,310.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant supports research conducted by Weill Medical College of Cornell University to investigate how the early-life intestinal microbiome and maternal antibodies influence the trafficking of commensal microbes to the thymus, which is critical for the development of the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,685,326 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant supports research to examine the role of CD101 in immune suppression, characterize functional responses of CD101-high neutrophils, investigate the mechanisms for Wnt5 to regulate splenic extramedullar hematopoiesis, and determine the transcription factors that control the molecular and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $571,091 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the role of gut regulatory T (Treg) cells and their interactions with the gut microbiome. The research aims to understand how microbial and food antigens establish gut Treg phenotypes and T cell receptor repertoires, particularly...
This federal Project Grant award of $195,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Davis to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, can inhibit the growth of the enteric pathogen Yersinia enterocolitica. The research aims to elucidate the molecular mechanisms underlying Y. enterocolitica's sensitivity and...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award, valued at $472,210.00 and effective June 23, 2025 through May 31, 2027, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research by the University of Massachusetts Medical School to investigate the spatiotemporal relationship between CD4+ T resident memory cells and neutrophil recruitment in the lungs during pneumonia in experienced...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,022,197 to the University of California, San Diego (UCSD) to study the role of regulatory T (Treg) cells and the IL-27 cytokine in maintaining intestinal immune homeostasis. The research aims to examine the molecular mechanisms driving IL-27 expression in gut Treg cells, as well as identify gut microbiome factors...