This $242,310 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the cellular and molecular mechanisms controlling the catabolism (breakdown) of the antibody IgE. The research aims to uncover novel receptors and cell types responsible for IgE clearance, as well as characterize how IgE glycosylation impacts its catabolism. This work could lead...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $442,024 to Trustees of Dartmouth College to elucidate the cellular mechanisms driving antibody effector functions. The research seeks to establish quantitative relationships between antigen, antibody, and effector biology in order to generate antibody design criteria that can predict and optimize...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,899,298 to Rockefeller University to conduct research on understanding the evolutionary processes governing antibody development within germinal centers. The key objectives are to develop a comprehensive toolset, including a mouse monoclonal model and deep mutational scanning experiments, to study the interplay...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $938,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant, titled "Identification of Novel Regulators for Neutrophil Development and Lifespan," aims to conduct a comprehensive genetic screen to identify new mechanisms that regulate neutrophil development and lifespan. The research will leverage immortalized mouse hematopoietic progenitor...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,083,816 to support research on the role of the CD79A molecule as a molecular switch regulating B cell activation. The research aims to determine how individual tyrosine phosphorylation sites on the CD79A immunoreceptor tyrosine-based activation motif (ITAM) impact B cell receptor (BCR) signaling, B cell development,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to improve the understanding of how antibodies can control viral infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The $318,085 award, effective from December 23, 2024 to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the role of immunoglobulin genetic diversity in the development of neutralizing antibodies against the HIV envelope protein. The $242,310 award to Emory University, spanning from August 2024 to February 2027, aims to identify polymorphisms in rhesus macaques associated with differential development of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate factors that enhance the protective capacity of antibodies through Fc-mediated immune responses. The $416,276 award to the University of Georgia Research Foundation will fund research to quantify how factors like epitope location, antibody glycosylation, and oligomerization affect the potency of...
This $130,368 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research aimed at defining how B cell receptor (BCR) binding site copy number at the cell surface is regulated to optimize antigen recognition and affinity-driven antibody selection. The primary objectives are to: 1) Determine the molecular mechanisms that underlie the developmental enhancement of BCR...
This federal Project Grant award of $107,948 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research aimed at engineering B cells to secrete broadly neutralizing antibodies that could help control HIV in people living with the virus. The key objectives are to: 1) design synthetic protein signaling molecules to enhance B cell function, 2) test the ability of these...