The University of Utah was awarded a $728,244 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of Salmonella's type III secretion system. The goal is to develop a better understanding of how this critical virulence mechanism in Gram-negative pathogens, including Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia, selects...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $219,122 to the University of Illinois to conduct research on the regulatory mechanisms governing Salmonella Typhimurium's virulence. The research aims to understand how small RNAs (sRNAs) and other post-transcriptional factors regulate the expression of the Salmonella pathogenicity island 1 (SPI1) type three secretion...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $204,347 to study the intracellular infection mechanisms of non-typhoidal Salmonella enterica (NTS) in human intestinal epithelial cells and macrophages. The key objectives are to: 1) Characterize the bacterial and host transcripts in infected cells harboring Salmonella in cytosolic versus vacuolar niches, 2)...
This federal Project Grant award of $238,787 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance the understanding of protein secretion by the ESX-1 system in mycobacteria, including pathogens like Mycobacterium tuberculosis. The research project, running from February 2025 to January 2027, will apply novel cell wall-specific protein tagging, surface-specific protein detection, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $207,370 to Duke University to investigate the role of the sigma factor SigE in modulating mycobacterial survival within granulomas, using a zebrafish-Mycobacterium marinum model. The research aims to uncover novel bacterial cell envelope components that impact both mycobacterial survival and the host immune...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize a novel bacterial immune system. The $125,160 award will fund efforts to use cryogenic electron microscopy and biochemical/cellular assays to define the structure, assembly, and functions of a two-component "inflammasome-like" system that bacteria use to defend against viral...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $206,251 to Duke University to conduct research on the molecular mechanisms by which the Salmonella Typhimurium pathogen hijacks the host STAT3 signaling pathway to promote an anti-inflammatory response and enhance its survival during oral infection. The research aims to elucidate how the Salmonella effector protein SARA...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,024,897 over a period of 5 years to support research aimed at understanding the innate immune response to Yersinia bacterial infection. The key focus is on investigating how monocyte-derived TNF and IL-1 signaling regulates the formation and function of pyogranulomas, which are organized immune structures...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $637,729 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College (Harvard Medical School) to investigate the molecular mechanisms underlying the activation and regulation of essential bacterial cell wall synthase enzymes. The 5-year research project aims to develop a detailed mechanistic understanding of these enzymes, which are critical targets for antibiotic...
This federal Project Grant award, valued at $771,690.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate syphilis pathogenesis through genetic engineering of the syphilis-causing bacteria Treponema pallidum. The award aims to leverage new capabilities to genetically manipulate T. pallidum in order to better understand the role of antigenic variation in the...