This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award for $246,623.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at New York University School of Medicine to study the molecular control of tolerogenic dendritic cell function. The research aims to characterize the dendritic cell subset responsible for maintaining T cell tolerance, including investigating aberrant cytokine...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $242,310 to Yale University to conduct research aimed at elucidating the cellular and molecular mechanisms governing the catabolism (breakdown) of immunoglobulin E (IgE). The research project seeks to uncover the receptors and cell types responsible for IgE clearance, as well as the impact of IgE glycosylation on its...
This $4,908,988 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The grant supports research to investigate the mechanisms by which gut microbiota and white adipose tissue control the CD4 T-cell compartment and facilitate the trafficking of these immune cells from the gut to the brain. The research aims to elucidate the gut-brain axis and its role in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,131,408 to Yale University over a period from Jul 25, 2025 to Jun 30, 2029. The funding supports research to elucidate the mechanisms behind high-efficiency beta-catenin protein degradation in B-lymphoid cells, investigate the cell-specific composition and function of repressive beta-catenin complexes, and develop therapeutic concepts to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $639,084 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to Childrens Hospital Medical Center in Cincinnati, Ohio. The grant, awarded on March 19, 2025, supports a research project titled "NAIVE CD8 T CELL FUNCTIONAL HETEROGENEITY" that aims to elucidate the heterogeneity of naive CD8 T cells and understand how this impacts immune responses and T cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $150,921 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA) to investigate the interplay between membrane rafts and biomolecular condensates in regulating T cell activation. The goal is to provide evidence and mechanistic insights on how these two cellular structures mutually regulate to tune T cell signaling, which can...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $661,693 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The University of Iowa. The grant, awarded on June 16, 2025, supports research to define the structure and function of a new family of peptidoglycan crosslinking enzymes found in Clostridioides difficile, an opportunistic pathogen and leading cause of hospital-acquired infectious diarrhea. The research aims to advance...