The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $737,502 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis. The grant, titled "Role of WDFY4 in Treg Development," will fund research to investigate a novel pathway involving the WDFY4 protein that regulates antigen presentation by dendritic cells and is critical for the development and function of regulatory T cells (Tregs). The proposed research aims to 1) determine the impact of WDFY4 on the T cell receptor repertoire, particularly in Tregs, 2) compare the MHC class I and II immunopeptidomes of dendritic cell subsets in the presence and absence of WDFY4, and 3) identify and validate WDFY4 interacting proteins. This research has the potential to advance the understanding of immune mechanisms underlying coordinated antigen presentation and the role of dendritic cells in maintaining immune tolerance, which could lead to new therapeutic approaches for autoimmune diseases, cancer, and infectious diseases.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $737.5k | 4/28/25 |