This federal Project Grant award for $246,623.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at New York University School of Medicine to study the molecular control of tolerogenic dendritic cell function. The research aims to characterize the dendritic cell subset responsible for maintaining T cell tolerance, including investigating aberrant cytokine...
This $797,735 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the cellular and molecular mechanisms governing heightened immune responses in neonates. The research project will utilize a novel mouse model to investigate how the innate immune system detects and mediates sterile inflammation during early life development, with the goal of developing targeted...
This Project Grant award, valued at $735,078, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports a 5-year research project to investigate the molecular mechanisms of innate immune memory in humans, with a focus on understanding the epigenetic determinants that enable long-lasting "trained immunity" in myeloid and lymphoid progenitor cells. The...
This $737,502 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the WDFY4 protein in regulating antigen presentation by dendritic cells for the development and maintenance of regulatory T cells (Tregs). The overarching goal is to better understand the immune mechanisms underlying coordinated antigen presentation, which could lead to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $631,977 Project Grant (CFDA 93.855 Allergy and Infectious Diseases Research) to Weill Medical College of Cornell University to conduct research aimed at enhancing immunological memory and reducing the burden of infectious diseases. The research will focus on understanding how caloric restriction induces metabolic reprogramming in memory CD8+ T cells to increase interferon production, which combines with...
This Project Grant award, valued at $162,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research at Indiana University Indianapolis to investigate the role of TGF-beta signaling in regulating T follicular helper (Tfh) cell differentiation and mast cell function, with the goal of better understanding the pathogenesis of allergic diseases. Key objectives include...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), will support research on the metabolic and epigenetic regulation of skin regulatory T cells (Tregs) at Emory University. The $597,542 award, spanning March 1, 2025 to February 28, 2030, aims to dissect the specific metabolic program governing the homeostasis of skin Tregs within their tissue microenvironment and...
This federal Project Grant award of $658,657, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Virginia on the biophysical and functional coupling of protein condensates to ordered lipid domains in T-cells. The research aims to reveal the mechanisms by which protein condensates and membrane domains cooperatively regulate T-cell signal transduction and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $707,534 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center. The grant supports research to investigate the mechanisms by which the ZFAND6 protein regulates mitophagy, inflammation, and the NLRP3 inflammasome. The research aims to provide new insights into the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $464,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on understanding and modulating the plasticity of T-helper 17 (Th17) cells. The research project aims to decipher the activity signatures of the AMP-activated protein kinase (AMPK) and its role in driving the transdifferentiation of Th17 cells into...