This $150,921 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the interplay between membrane rafts and protein condensates regulates T cell signaling and activation. The goal is to characterize the biophysical properties of membranes coupled to the LAT protein condensates, and evaluate the effects of membrane lipid remodeling on LAT...
This federal Project Grant award, totaling $472,210.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the award is to investigate the spatiotemporal relationship between CD4+ T resident memory cells and neutrophil recruitment in the lungs during pneumonia, while developing a transcriptional atlas of immune processes in the experienced lung. Key objectives include...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop an innovative proteoliposome-based delivery system for therapeutic and bioactive cargo. The $213,284 award will fund research to repurpose viral fusion machinery, including proteins from influenza, Nipah virus, and SARS-CoV-2, to improve cellular uptake and targeted delivery of user-defined cargo. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085.00 to conduct research on the role of cell, antigen, and antibody in controlling virus infection through Fc-dependent mechanisms. The key focus is on understanding how to optimize antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the molecular mechanisms underlying T cell dysfunction and HIV persistence in persons with HIV (PWH). The $500,000 award, effective from September 1, 2024 to August 31, 2029, will support research conducted by The General Hospital Corporation (Massachusetts General Hospital) to identify and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $693,465 to Cornell University to conduct research on mapping infant and adult T cell immunity. The project aims to construct the first molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T cell priming throughout...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This federal Project Grant award of $534,000 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research by The Children's Hospital of Philadelphia (CHOP) to investigate how the location of antigens and the density and half-life of peptide:MHCII complexes on antigen-presenting cells drive CD4+ T cell differentiation and functionality. Specifically, the research aims to 1)...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $639,084 to the Children's Hospital Medical Center in Cincinnati, Ohio to conduct research on the heterogeneity of naive CD8 T cells and their role in immune response and homeostasis. The research aims to elucidate how naive CD8 T cell heterogeneity contributes to protective immunity against pathogens and...
This $737,502 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the role of the WDFY4 protein in regulating antigen presentation by dendritic cells and its impact on regulatory T cell (Treg) development and function. The key objectives are to: 1) Determine the effect of WDFY4 on the T cell receptor repertoire, particularly in Tregs, to...