This Project Grant award, ID R21AI190507, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $264,750 award will fund research to explore the molecular regulation and functional impact of integrin CD11a on the positioning and interactions of lymph node-resident dendritic cells (DC1) with migratory dendritic cells. This research aims to enhance understanding of cellular organization in...
This federal Project Grant award of $350,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop polymer-derived biomaterials for messenger RNA (mRNA) delivery to induce antigen-specific immune tolerance. The award supports research to evaluate diverse nanocarrier formulations encapsulating antigens and mRNAs encoding tolerogenic proteins, investigate the biodistribution and...
This Project Grant award, valued at $379,609.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to investigate how B cells establish tolerance to commensal microbial antigens, using a mouse model system expressing B cell receptors (BCRs) specific for a model commensal antigen, lipopolysaccharide (LPS). The research will formally define the mechanisms by which a ubiquitous...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $693,465 to Cornell University to conduct research on mapping infant and adult T cell immunity. The project aims to construct the first molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T cell priming throughout...
This federal Project Grant award of $417,984 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research conducted by the Scripps Research Institute to identify small molecule compounds that can selectively induce the differentiation of functional regulatory T cells (Tregs). The research aims to address challenges in expanding Treg populations without causing unintended...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 Allergy and Infectious Diseases Research, provides $423,500.00 to the Regents of the University of Minnesota to investigate the role of the spleen in maintaining immune tolerance to transplanted islets. The key objectives are to comprehensively profile alloreactive regulatory T cells (Tregs) and exhausted T cells in the spleen, and analyze their spatial interactions, to...
The federal Project Grant award R03AI190276, totaling $164,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this award is to identify and characterize additional conformer-specific anti-I-A monoclonal antibodies (mAbs) that can be used as investigative tools to study the role of different I-A class II MHC molecule conformers in T cell receptor interactions, lipid raft...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $138,051 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Minnesota. The grant supports research to understand the role of thymic B cells in regulating immune tolerance and autoimmune diseases. The research aims to investigate how type-III interferon-driven licensing of thymic B cells impacts the development of T regulatory cells that become...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,286,273.00 to The Trustees of Columbia University in the City of New York to conduct preclinical studies on inducing liver transplant tolerance. The research aims to develop clinically applicable protocols for tolerance induction in living and deceased donor liver transplantation, as well as to define the...
This federal Project Grant award of $649,053 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University. The grant supports research to investigate the role of the Ly49 family of receptors on CD8 T cells and their function in regulating immune responses. Specifically, the research aims to understand how Ly49 and the transcription factor Helios contribute to the development...