The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,297,775 Cooperative Agreement under the Allergy and Infectious Diseases Research program (CFDA 93.855) to National Jewish Health in Denver, Colorado. The funding will support a research project titled "SUNBEAM Birth Cohort: Deciphering the Role of Early Life Skin Dysfunction in Development of the Allergic March." The project aims to evaluate whether early-life skin pathobiology leads to the development of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $735,078 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Chicago to conduct research on the molecular mechanisms of innate immune memory, also known as trained immunity, in humans. The project aims to investigate the epigenetic changes induced by trained immunity adjuvants, how these changes are transmitted from hematopoietic stem cells to differentiated immune cells,...
This $693,465 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research by Cornell University to construct a molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T cell priming throughout childhood. The research aims to provide a new paradigm for understanding T cell activation and...
This $769,366 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to decipher the development and maintenance of CD4+ resident memory T cells in the skin, which can provide long-lasting protection against cutaneous leishmaniasis, a neglected tropical disease with no effective vaccine. The research aims to: 1) determine if precursor dermal...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $639,084 to support research aimed at elucidating the heterogeneity of naive CD8 T cells and how this contributes to immune response and T cell homeostasis in mice. The research will also define a human naive CD8 T cell atlas by examining antigen-specific CD8 T cells in young, aged, and newborn populations....
This $107,948 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to investigate the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skin. The two-year project, running from February 1, 2025 to August 25, 2027, aims to determine whether CD8 tissue-resident memory T cells in the skin can orchestrate an immune...
This $2,483,910 Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into novel genetic mechanisms underlying primary immune regulation disorders (PIRD), a subset of inborn errors of immunity (IEI). The research team at The Washington University will use a three-pronged approach to investigate: 1) epigenetic regulation of immune system genes through...
This federal Project Grant award of $219,456 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand how sterile inflammation at the maternal-fetal interface impacts the developing fetal immune system in a non-human primate model. The research aims to test the hypotheses that 1) injecting the clotting agent Tisseel into the maternal-fetal interface leads to placental inflammation, and 2) this...
This federal Project Grant award of $606,501 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the role of the BAF chromatin remodeling complex in regulating germinal center B cell responses. The overarching goal is to provide comprehensive mechanistic insights into how the ARID1A-dependent canonical BAF complex (ARID1A-cBAF) establishes the germinal center transcriptional...
This $126,174 Federal Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to utilize a novel skin-on-a-chip model to investigate extramedullary granulopoiesis and immune responses in human skin, with the goal of providing insights into combating antibiotic-resistant skin infections. Specifically, the research aims to: 1) Demonstrate the HSPC signaling...