Project Grant R01AI185075
- This $108,115 Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports comprehensive characterization of lentiviral vector (LVV) integration and impact on host cell biology using novel genomic technologies. The research aims to provide a deeper understanding of LVV integration patterns and cellular transformation, which has emerged as a critical safety...
- This federal Project Grant award for $782,871.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate mechanisms by which arthritogenic alphaviruses, such as chikungunya and Ross River viruses, evade CD8+ T cell-mediated immune responses. The research aims to define how type I interferon signaling restricts infection of antigen-presenting myeloid cells, limiting...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $808,919 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Boston University. The 5-year grant, which began on September 18, 2025, aims to develop novel aglain derivatives as host-targeted antivirals against dengue virus (DENV) and other mosquito-borne arboviruses. The research program seeks to optimize the aglain chemical series and study their modulation of the host...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,047,991 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant, awarded on September 12, 2025, will fund research to investigate the molecular basis for paired receptor signaling in antiviral natural killer (NK) cells during murine cytomegalovirus (MCMV) infection. The research aims to delineate how NK cell receptor...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $506,530 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Albert Einstein College of Medicine. The award, effective November 20, 2024 through October 31, 2026, supports research to investigate the role of cell-to-cell transmission in alphavirus infection and disease. Specifically, the research aims to: 1) determine the mechanisms by which antibodies can block...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $423,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M University System Health Science Center. The grant, awarded on July 17, 2025, aims to develop an intein-based QF2 system for controllable protein expression in the nervous system of the Aedes aegypti mosquito. This research seeks to leverage genetic and synthetic biology tools to disrupt the propagation of...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, provides $138,213 to The Trustees of Princeton University to conduct research on viral genetic interactions and mutations. Specifically, the research aims to systematically study the molecular mechanisms by which 4 strains of the lymphocytic choriomeningitis virus (LCMV) cause distinct impacts on the liver and...
- This Project Grant award of $507,121 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Duquesne University supports research on RNA homodimerization strand displacement pathways and their relationship to viral mechanisms. The research aims to characterize the structural, dynamic, and energetic details of kissing complexes and extended duplexes - two interconverting RNA structures implicated in processes like viral genome...
- This Project Grant award, valued at $681,755.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into the intracellular assembly, maturation, and trafficking of glycoprotein complexes from four rodent-infecting hantaviruses. The research aims to delineate the virus-host interactions required for the proper localization and function of these glycoprotein complexes, which...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $530,385.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on how host cell factors regulate the activity of the essential flaviviral enzyme NS3 in viral pathogens like dengue, Zika, and West Nile viruses. The research aims to define in detail how...
The University of Louisville was awarded a $1,981,840 federal Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to comprehensively define the impact of a novel interaction between the alphaviral capsid (CP) protein and the host IRAK1 protein. This research aims to delineate the role of this interaction in alphaviral pathogenesis, define its molecular impacts on host cellular biology, and determine its consequences on the alphaviral CP protein. The 4-year project, commencing on September 4, 2025, seeks to advance scientific understanding of the mechanisms by which alphaviruses evade or dysregulate the host innate immune response, with the goal of informing the development of innovative antiviral strategies against these mosquito-borne pathogens.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/4/25 |