This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $441,502 to the University of Texas Health Science Center at Houston (UTHealth) to advance CRISPR-based genome editing strategies for managing Aedes aegypti mosquito populations. The key objectives are to: 1) design a CAS12 temperature-dependent system that requires only one strain to produce sterile male...
This $588,514 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop new tools for improving mosquito population suppression technologies in Aedes aegypti, a key disease vector. The key focus areas include: Evaluating conditional and sex-specific lethal systems that can restrict lethal transgene expression to reduce fitness load on the mosquito population. This includes...
This federal Project Grant award of $429,000.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine chromatin architecture and gene regulatory networks in Anopheles coluzzii mosquito hemocyte cells. The key objectives are to 1) map chromatin architecture during immune activation in mosquito hemocyte cells, and 2) identify gene regulatory networks for the immune...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $329,039.00 to the University of Florida to conduct research on the dispersal biology and population genetics of the invasive Aedes aegypti mosquito. The key objectives are to: (1) determine the genetic relatedness and effective population size of Ae. aegypti populations from diverse environments, and (2) identify genes under...
This Project Grant award of $211,038 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at The Johns Hopkins University to investigate a new strategy for controlling mosquito populations. The key focus is on targeting the enzyme iodotyrosine deiodinase, which plays a critical role in protecting insects like fruit flies from the accumulation of harmful halotyrosines that can suppress...
This Project Grant award of $699,814 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, aims to study molecular mechanisms of Plasmodium parasite invasion in Anopheles mosquito midguts to identify novel targets for transmission-blocking malaria vaccines. The key products and services to be delivered under this award include: Functional characterization of identified mosquito and parasite proteins that mediate...
The National Science Foundation awarded a $500,000 Project Grant to the University of Washington under the Biological Sciences federal grant program (CFDA 47.074) to investigate olfactory learning and neuromodulation in the Aedes aegypti mosquito from June 1, 2023 to May 31, 2026. The research aims to understand how odor learning modifies mosquitoes' biting behaviors through three objectives: testing whether mosquitoes only learn certain odors corresponding to antennal lobe glomeruli tuning;...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $648,924 to Iowa State University of Science and Technology to conduct research on the role of mosquito extracellular vesicles in malaria parasite killing and immune priming. The project aims to obtain a mechanistic understanding of how these extracellular vesicles function within the mosquito immune system...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $103,256 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Medical College of Wisconsin, Inc. The grant, entitled "Effects of a Chromosomal Inversion on Gene Regulation in a Major Malaria Vector", aims to study the mechanisms by which a chromosomal inversion in Anopheles coluzzii mosquitoes confers resistance to malaria infection. The research will biochemically and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $401,185 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the Board of Regents of the Nevada System of Higher Education, operating through the University of Nevada, Reno. The grant supports research to define the mechanism of action of the broadly-active antiviral mosquito protein ABRAVO. The project aims to generate new tools to study ABRAVO, determine the key...