Project Grant R21AI188908

Award Date 11/20/24
Completion Date 10/31/26
Dollars Obligated $507K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Bronx, NY 10461, USA
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This Project Grant award, in the amount of $506,530, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855).

The primary objective of this 2-year grant is to define the mechanisms by which antibodies can block cell-to-cell transmission of alphavirus infections, such as chikungunya virus (CHIKV) and Mayaro virus (MAYV). The research will: 1) Determine how antibodies target viral envelope proteins to inhibit cell-to-cell spread, including evaluating patient sera for this activity; and 2) Elucidate the contribution of cell-to-cell transmission to alphavirus cellular tropism, dissemination, disease progression, and persistence in vivo using mouse models.

This project involves a collaborative effort between researchers at Albert Einstein College of Medicine and the University of Colorado-Denver, who will serve as a sub-awardee receiving $312,614 to support their research activities.

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