Project Grant R01AI189798
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
- This $666,567 federal Project Grant was awarded on May 13, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to identify the transcriptional regulators of human natural killer (NK) cell function following viral infection, with a focus on the role of the transcription factor MEF2C. The research aims to understand how MEF2C regulates NK cell cytotoxicity, proliferation, and...
- The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $3,519,992 to the Sloan-Kettering Institute for Cancer Research to conduct research on the chromatin architecture regulating trained immunity in antiviral natural killer (NK) cells. The research aims to better understand the molecular mechanisms that underlie trained immunity in NK cells, which play a...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $164,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Albany Medical College. The grant supports research to identify and characterize additional conformer-specific anti-I-A monoclonal antibodies (mAbs) to study the structure and function of MHC class II molecules, which are important for T cell-mediated immune responses. The research aims to address limitations in existing...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $232,415 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Davis. The goal of this 2-year award, with a period of performance from November 2024 to October 2026, is to develop a highly potent monoclonal antibody that can neutralize the cytomegalovirus (CMV)-encoded interleukin-10 (IL-10) protein, in order to prevent primary CMV infection and reduce the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $743,752 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Utah. The grant will support research to define how chronic antigen stimulation contributes to epigenetic programming that drives dysfunction in virus-specific CD4+ T cells during chronic viral infection. The project aims to use highly innovative in vivo models and whole genome DNA methylation sequencing...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $156,080 to the University of Utah to study the role of the LY49C inhibitory receptor in modulating natural killer (NK) cell functions. The research aims to determine how LY49C binding to MHC-I with different peptides can lead to divergent NK cell effector functions, despite the lack of direct peptide interactions. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $831,235 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Southern California (USC) to explore a key nucleotide synthesis enzyme as a potential target for developing broad-spectrum antiviral therapies. The project, led by Co-PIs Pinghui Feng and Chao Zhang, aims to genetically interrogate the enzyme's role in viral immune evasion and metabolic reprogramming...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, awarded a $192,260 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant will fund research to characterize the systemic and mucosal immune response to adenovirus 40/41 infection in Bangladeshi children and determine the efficacy of breast milk antibodies in providing...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research grant program (CFDA 93.855), provides $463,676 to the University of Maryland, Baltimore for research to enhance the understanding of Fc-mediated effector functions in the context of infectious diseases. The project aims to dissect the mechanisms underpinning Fc-mediated effector functions, with a focus on antibody interactions with a...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,047,991 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant, awarded on September 12, 2025, will fund research to investigate the molecular basis for paired receptor signaling in antiviral natural killer (NK) cells during murine cytomegalovirus (MCMV) infection. The research aims to delineate how NK cell receptor polymorphism affects antiviral immunity and the mechanisms of paired receptor virus control. The project will utilize single-cell sequencing and mass spectrometric proteome analysis to identify NK cell signaling pathways involved in virus control. Key findings will be further tested to understand the basis of paired receptor-mediated antiviral immunity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 9/11/25 |