The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $530,385 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant, awarded on June 6, 2025, will support research to define how the host acetylation enzyme KAT5 regulates the enzymatic activities of the essential flavivirus protein NS3, which is critical for viral replication. Using molecular, biochemical, and cell biological approaches, the project aims to provide a detailed mechanistic understanding of how KAT5-mediated acetylation of NS3 controls flavivirus infection and associated pathology for viruses like dengue, Zika, and West Nile. This research may lay the foundation for new, potentially broadly effective therapeutic approaches targeting flavivirus infections.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $530.4k | 6/6/25 |