Project Grant K99AI182471
- This $410,000 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research conducted by The Trustees of Princeton University to examine the influence of chromosome copy number on persistence of the Pseudomonas aeruginosa bacterium to fluoroquinolone antibiotics. The research aims to better understand the genetic basis for antibiotic persistence in this common hospital-acquired...
- This $108,115 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to comprehensively characterize lentiviral vector (LVV) integration and impact on host cell biology using novel genomic technologies. The research will investigate LVV integration profiles and proviral integrity, which are critical for the safe development of LVV-derived cell therapies like chimeric antigen receptor (CAR) T-cells that have...
- This $102,444 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Yale University supports research to uncover structural insights into the N-terminal core of the SARS-CoV-2 nonstructural protein 1 (NSP1) and establish its specificity in regulating host gene expression. The goal is to contribute to the mechanistic understanding of coronavirus pathogenesis and evolution, which could aid in the development...
- This federal Project Grant award of $109,076 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the role of the immunometabolite L-2-hydroxyglutarate (L-2HG) in natural killer (NK) cell antiviral immunity. The award recipient, Weill Medical College of Cornell University, will use the funding to study how L-2HG accumulation impacts the metabolic and epigenetic state of NK cells and their...
- This $104,952 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate a new mechanism for maintaining B cell genome integrity by degrading Line-1 (L1) retrotransposon RNA. The principal investigator at The Trustees of Columbia University plans to use in vitro assays, biochemical/molecular approaches, and long-read sequencing to determine if the RNA exosome, an RNA processing...
- The U.S. National Institute of Allergy and Infectious Diseases (NIAID) awarded a $256,995 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to Tufts University School of Medicine. This 2-year grant, awarded on April 1, 2025, will fund research to quantitatively link the intracellular traits of the bacterial pathogen Legionella pneumophila to host cell mutations using optical sequencing. The project aims to overcome limitations in current approaches for...
- This federal Project Grant award of $415,250.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to investigate how a novel type of myeloid cell, known as long-lived highly differentiated monocyte-derived cells (LDMs), regulates lung-resident memory T cells (Trm) during respiratory viral infections. The research, conducted by the University of Rochester, seeks to enhance understanding of the lung's unique immune system...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $777,360 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Washington University in St. Louis to conduct research on advancing the elimination of lymphatic filariasis, a mosquito-borne infection that can lead to long-term disability. The research aims to use genomic epidemiology to better understand the causes of persistent or resurgent lymphatic filariasis...
- This $1,687,240 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports the development of new broadly inhibitory antibody therapies for alphavirus infections. The award to Albert Einstein College of Medicine aims to engineer Fc mutations into broadly protective human monoclonal antibodies to enhance their in vitro and in vivo properties, and to perform viral escape studies to understand neutralization...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
The federal Project Grant award of $138,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project to systematically dissect the genetic interactions and mutations of the lymphocytic choriomeningitis virus (LCMV). The awardee, The Trustees of Princeton University, will perform comparative genomics to study the molecular mechanisms by which subtle genetic differences between LCMV strains can lead to distinct impacts on the liver and immune system. The research will leverage a novel combinatorial genetic expression screening approach, called COEXPRES-seq, to quantify the individual and combined effects of LCMV genes on cellular pathways in hepatocytes and dendritic cells. This foundational work is expected to advance the understanding of how viral genotypes influence complex disease phenotypes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $138.2k | 8/18/25 |