Project Grant R01AG102849
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Dana-Farber Cancer Institute, Inc. a Project Grant totaling $737,261 under the Aging Research program (CFDA 93.866), effective July 1, 2026, through March 31, 2031. This award funds research to elucidate the functional consequences of TERT (telomerase reverse transcriptase) missense rare variants and their relationship to age-related telomere dysfunction and clonal hematopoiesis. The research combines genetic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts Institute of Technology a $723,962 Project Grant on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a systems-level analysis of DNA damage and repair mechanisms in cellular senescence, aging, and cancer. The five-year project, concluding February 28, 2031, will deliver comprehensive research findings on the spectrum of DNA lesions occurring in human cells and tissues,...
- Federal Project Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $445,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on March 10, 2026, with a completion date of December 31, 2032. The award funds fundamental research to elucidate the origins and drivers of clonal dynamics in hematopoiesis—specifically, the mechanisms by which hematopoietic stem cell (HSC) clones expand,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $463,000 Project Grant to Massachusetts General Hospital's Research Management Division, effective May 1, 2026 through January 31, 2031, under the Aging Research program (CFDA 93.866). This award funds basic research designed to identify and characterize cytoplasmic chromatin fragments (CCF) that accumulate during cellular senescence and aging. The research team will utilize cGAS (cyclic guanosine monophosphate–adenosine...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $157,760 to Massachusetts General Hospital's Research Management Division on August 20, 2026, under the Aging Research program (CFDA 93.866). The award supports a one-year research project investigating a novel mechanism of autophagic degradation in cellular senescence. The research focuses on understanding how autophagy—a cellular self-digestion process—functions specifically in senescent...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $690,865 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on January 15, 2026, under the Aging Research program (CFDA 93.866) to support research examining the relationship between mitochondrial function and resilience in human aging. The research will leverage two unique human datasets—the MISBIE Study (patients with and without genetically determined...
- Project Grant Award Summary Fred Hutchinson Cancer Center received a $2.59 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with a completion date of August 31, 2029. This research project investigates adipocyte-derived lipid and mitochondrial signals and their mechanisms in neuroprotection and brain senescence. The research deliverables include scientific findings on how adipocyte-derived lipoproteins...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $1.56 million Project Grant (CFDA 93.866, Aging Research) to Fred Hutchinson Cancer Center in Seattle, Washington on April 15, 2026, with a completion date of March 31, 2031. This grant funds research investigating immune aging phenotypes in adult survivors of childhood hematologic malignancies and their association with chronic health conditions including congestive heart failure, coronary artery disease, and...
- Federal Project Grant Award Summary The Broad Institute, Inc. received a $1.22 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for May 31, 2030. The grant funds research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease, specifically investigating how interactions between nuclear genes and mitochondrial DNA (mtDNA) contribute to Alzheimer's disease...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Fred Hutchinson Cancer Center a Project Grant totaling $1.57 million under the Aging Research program (CFDA 93.866), with an award date of June 1, 2026, and completion date of May 31, 2031. This research initiative investigates Clonal Hematopoiesis of Indeterminate Potential (CHIP) in aging and exceptional longevity among older women, responding to the NIA's special notice on women's health research aimed at extending...
Dana-Farber Cancer Institute, Inc. received a $696,914 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective July 15, 2026, through June 30, 2031. The award supports biomedical research focused on rejuvenating aged hematopoietic stem cells (HSCs) and their bone marrow niche through mitochondrial engineering. The research addresses critical gaps in hematopoietic stem cell transplantation (HSCT) by investigating how mitochondrial dysfunction contributes to age-related HSC decline and developing therapeutic approaches to restore mitochondrial integrity and intercellular mitochondrial communication between HSCs and mesenchymal stromal cells (MSCs). The funded research deliverables include scientific investigations into mitochondrial transfer mechanisms between HSCs and MSCs, preliminary studies on mitochondrial supplementation to rescue aged HSC function, and translational work examining how targeted mitochondrial engineering can restore self-renewal capacity and reduce clonal hematopoiesis-associated mutations in aged donor cells. These findings are expected to advance understanding of aging-related hematopoietic dysfunction and generate evidence supporting improved transplant outcomes for HSC-based therapies in aging populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $696.9k | 7/17/26 |