Project Grant R01AG098480
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $2.59M Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded September 15, 2025, with completion targeted for August 31, 2029. The research project aims to elucidate mechanisms of adipocyte-brain communication and their impact on glial function, neuroprotection, and brain aging, with potential implications for preventing dementia and age-related cognitive decline. The...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $132,705.00 on June 15, 2025, to The Children's Hospital Corporation (Boston Children's Hospital) under the Aging Research program (CFDA 93.866). This award supports research addressing hematopoietic clonal dominance during aging—a condition in which driver mutations cause a limited number of hematopoietic stem and progenitor cell (HSPC) clones to disproportionately contribute to blood cell...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a $1,746,856 Project Grant under the Aging Research program (CFDA 93.866) on August 5, 2025, with a completion date of April 30, 2030. The grant funds research investigating the role of senescent cancer-associated fibroblasts (SENCAFs) in breast cancer progression, with particular emphasis on age-related changes in the tumor microenvironment. The research addresses a significant public health need, as...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pittsburgh a $3.1 million Project Grant under the Aging Research program (CFDA 93.866) for the period September 1, 2025, through August 31, 2029. This research project investigates the mechanistic link between persistent DNA damage and the immune response pathway in aging and DNA repair-deficient conditions. The award supports biomedical research directed toward understanding how the NLRP12 (NOD-like...
- Federal Project Grant Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded $393,750 to the University of California, Los Angeles on September 22, 2025, to conduct a prospective cohort study evaluating the impact of gastroesophageal cancer (GEC) treatments on physical function in older adults aged 60 years and above. The research project, with completion scheduled for August 31, 2027, will deliver scientific evidence through serial geriatric...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania $243,000 under the Aging Research program (CFDA 93.866) on September 5, 2025, with a completion date of May 31, 2030. This project grant supports research investigating the impact of frailty on disease relapse and therapy intensity in older adults with acute myeloid leukemia (AML), with particular focus on identifying biomarkers and optimizing treatment selection. The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Miami a Project Grant totaling $109,652.00 under the Aging Research program (CFDA 93.866) on September 5, 2026, with a completion date of September 4, 2027. This award supports research investigating T cell senescence-driven immune dysfunction in aging and HIV-positive populations. The research project aims to elucidate the mechanisms by which senescent T cells—cells that have undergone stable cell...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $1,080,528 Project Grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). This grant supports fundamental research investigating the mechanisms by which senescent stromal cells drive chemotherapy-induced peripheral neuropathy (CIPN), a debilitating condition affecting up to 90% of cancer patients receiving taxane chemotherapy, with 30%...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $463,625 under the Aging Research program (CFDA 93.866) to conduct biomedical research on lung adenocarcinoma (LUAD) and its relationship to patient age. The award, which commenced September 1, 2025, and extends through August 31, 2027, funds research to understand how aging affects the LUAD tumor microenvironment (TME) and to identify therapeutic...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $399,852.00 to the Regents of the University of Minnesota under the Cancer Cause and Prevention Research program (CFDA 93.393) for the period May 1, 2026, through April 30, 2028. This research initiative will develop and validate circulating senescent-associated secretory phenotype (SASP) protein indexes to assess accelerated aging in cancer survivors. The primary deliverable involves creating...
The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a Project Grant of $762,675 to Fred Hutchinson Cancer Center (doing business as Seattle Cancer Care Alliance) on April 15, 2026, with a completion date of March 31, 2031. This research initiative investigates immune aging phenotypes in adult survivors of childhood hematologic malignancies, specifically examining how the immune system changes in long-term cancer survivors and whether these changes correlate with chronic health conditions such as congestive heart failure, coronary artery disease, and frailty. The project applies high-dimensional immunological approaches to characterize aging-associated immune dysfunction in childhood cancer survivors compared to healthy comparison groups, with the ultimate goal of identifying modifiable risk factors and intervention strategies to reduce long-term morbidity in this population. The grant supports translational research that combines expertise in immunology and cancer survivorship to test the hypothesis that survivors of childhood hematologic malignancies exhibit distinct aging-associated immune phenotypes linked to chronic health conditions. By elucidating the relationship between immune aging, inflammation, and cardiovascular disease development in cancer survivors—a population that experiences accelerated aging compared to the general population—this research addresses a significant gap in understanding post-treatment health outcomes and may inform future interventions to improve quality of life and lifespan in this vulnerable patient population.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $762.7k | 4/17/26 |