Project Grant R01AG092819
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Broad Institute of MIT and Harvard a Project Grant of $610,836 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through May 31, 2030. This award supports research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant totaling $475,377 on September 5, 2025, under the Aging Research program (CFDA 93.866) through its Health Sciences Division. The grant funds a two-year research initiative (completion date: August 31, 2027) to investigate the functional significance of FOXO3 (Forkhead Box O-3) in microglial cells and its role in Alzheimer's Disease (AD)...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 through the Aging Research program (CFDA 93.866) to conduct a comprehensive genetic mapping study of RNA modifications in the aging human brain and their association with Alzheimer's disease (AD). This project grant, initiated September 1, 2025, with completion targeted for May 31, 2030, will deliver a multi-faceted research effort examining how genetic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a $2,957,210 Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award funds comprehensive biomedical research investigating the role of CD44 astrocytes in Alzheimer's disease (AD) pathophysiology. The research project will elucidate the functional mechanisms by which CD44 upregulation...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant of $6,290,600 under the Aging Research program (CFDA 93.866), effective August 1, 2025, through July 31, 2029. This research initiative employs integrated multi-omics approaches combined with biochemical and functional methodologies to investigate how the ubiquitin-proteasome system (UPS), specifically proteasome complexes, are affected across...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $699,344 project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2027. The award funds research investigating the relationship between surgical stress, physiologic resilience, and sex-dependent vulnerabilities in aging hallmarks. The research employs a two-phase approach, with the R61 phase establishing the spatial, temporal,...
- Federal Grant Award Summary This Project Grant award of $109,076, issued on March 3, 2026, by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research investigating vulnerable cell populations in aging-induced circadian clock remodeling and disruption through March 2029. The primary deliverable is a comprehensive scientific investigation utilizing high-throughput single-nucleus RNA sequencing (snRNA-seq) of flash-frozen tissue samples to identify key cell...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $3.45 million Project Grant under the Aging Research program (CFDA 93.866) for a four-year period from September 1, 2025, through August 31, 2029. This award supports research investigating the molecular mechanisms and genetic basis of human ovarian aging in response to Notice NOT-OD-24-079 on women's health research. The project will deliver comprehensive scientific...
- Federal Project Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $2,991,725 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, with a completion date of August 31, 2029. This award funds a comprehensive research initiative investigating reactive oxygen species (ROS) as modulators of lifespan and aging processes. The research examines how early-life...
- Federal Project Grant Award Summary J. David Gladstone Institutes received a $793,777 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 17, 2025, with a completion date of April 30, 2030. The award funds a comprehensive research project investigating mitochondrial DNA (mtDNA) compaction and the accumulation of somatic mutations with age and stress. The primary deliverable is an enhanced understanding of how mitochondrial...
The National Institute on Aging awarded The Trustees of Columbia University in the City of New York a $690,865 Project Grant (CFDA 93.866 - Aging Research) effective January 15, 2026, with completion targeted for December 31, 2030. This award supports a comprehensive research initiative examining the mitochondrial and energetic underpinnings of resilience in human aging. The research leverages two unique human datasets—the MISBIE Study (which includes patients with genetically determined mitochondrial disease) and the Baltimore Longitudinal Study of Aging (BLSA), one of the longest-running aging cohort studies—to establish links between oxidative phosphorylation (OXPHOS) capacity and physiological resilience. The project delivers three primary research products and services: (1) empirical assessment of the relationship between mitochondrial OXPHOS capacity and resilience across both datasets, including novel proteomics-based resilience metrics; (2) mechanistic investigation of GDF15 and FGF21 signaling pathways that may connect altered mitochondrial biology to downstream organismal effects; and (3) development of a novel "mito-health clock" designed for deployment in epidemiological and clinical studies as a practical proxy for expensive and challenging direct mitochondrial biology measurements. By triangulating genetic and epidemiological evidence, the research aims to advance geroscience understanding of how mitochondrial dysfunction contributes to diminished resilience and age-related disease risk in humans.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $690.9k | 1/12/26 |