Project Grant K25AG095370
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- This $846,358 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to build a research platform to assess the senescence-associated secretory phenotype (SASP) in vivo. The goal is to elucidate the molecular identity of the SASP secretome and develop biomarkers to distinguish senescence and SASP signatures across different tissues. To accomplish this, the award will leverage a novel SASP-ER platform that permits conditional tagging of secreted proteins in...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This $109,076 project grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) on November 27, 2025, aims to investigate the impact of modulating synovial mechanobiology to mitigate disease progression in osteoarthritis (OA). The project will evaluate the effect of genetic and pharmacologic suppression of non-muscle myosin II (NM-II) on fibroblast-like synoviocyte (FLS) activation, synovial fibrosis, and OA pathogenesis using in vitro and in vivo models. The research is...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,126,515 to Trustees of Indiana University in Indianapolis, IN to conduct research aimed at understanding how the L-BAIBA/FGF23 axis, an interaction between muscle and bone, can be targeted to enhance musculoskeletal health and resilience in aging populations. The research seeks to elucidate the mechanisms by which this muscle-bone signaling pathway becomes dysregulated with age, leading to...
- The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $506,000 Project Grant to the Scripps Research Institute to engineer a novel biomolecular condensate (BMC)-based tool with tunable physicochemical properties. The goal is to create an orthogonal selective autophagy receptor (SAR)-like BMC capable of supporting autophagosome biogenesis and selective cargo recruitment. This will enable detailed investigation of the biophysical regulatory mechanisms of BMCs in autophagy, which...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
This $146,070 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology in a 3D bone-mimicking microenvironment. The goals are to: (1) acquire experimental skills and career training to expand the researcher's program into cellular aging/senescence and molecular biology; (2) investigate how local vs. systemic senescent cells and their secretory phenotypes influence osteocyte cytoskeletal stiffness, membrane viscoelasticity, and responses to mechanical stimuli; and (3) generate data to support future NIH R01 applications. The project will leverage novel 2D and 3D co-culture models using visible light-induced 3D bioprinting techniques to mimic the bone microenvironment and study the reciprocal effects of senescence between osteocytes and bone marrow mesenchymal stem cells. The award is effective from September 1, 2025 through May 31, 2030 and will be performed at the University of Texas at Austin.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $146.1k | 8/26/25 |