Project Grant R01AG099232
Award Date 9/1/26
Completion Date 8/31/31
Dollars Obligated $620K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15213, USA
Similar Awards
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging awarded the University of Pittsburgh $673,702 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research deciphering ubiquilin-mediated proteostasis mechanisms in Alzheimer's disease and related dementias. The research addresses knowledge gaps in ubiquilin function and protein homeostasis defects underlying neurodegenerative disease. The project will elucidate how STI1 domain binding and E3 ligase recruitment affect cellular fitness...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Pittsburgh $2,003,400 on September 15, 2025, under the Aging Research program (CFDA 93.866) to characterize white matter injury in Alzheimer's disease. The research investigates risk factors for and consequences of white matter injury in brain regions affected by Alzheimer's pathology using a novel, spatially precise measurement method called unhealthy...
- The National Institute on Aging awarded Purdue University $387,183 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop mass spectrometry-based proteomics strategies examining post-translational modifications related to protein aggregation and extracellular vesicle-mediated propagation in neurodegenerative disease, with emphasis on Alzheimer's disease. The recipient will establish a novel proteomics platform to profile N-terminal acetylation landscapes in primary...
- The National Institute on Aging awarded the University of Washington $575,342 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical and artificial intelligence tools that elucidate cognitive resilience in Alzheimer's disease by linking region-resolved neuropathology with cell-type programs, particularly microglia function. The project integrates quantitative digital neuropathology with single-cell and spatial molecular profiles to build methods that estimate...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institutes of Health's National Institute on Aging awarded $256,331.40 under the Aging Research program (CFDA 93.866) to The Trustees of the University of Pennsylvania from February to October 2021. The project aims to develop novel machine learning algorithms and biomedical software to more accurately quantify brain aging and predict the onset of neurodegenerative diseases such as Alzheimer's. Specifically, the funding will support refining predictive models of the...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the University of Pittsburgh $424,913 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize LAMP5 interneurons in the human entorhinal cortex and their vulnerability to tau-related Alzheimer's disease neuropathology across the aging lifespan. This R21 exploratory grant funds investigation of the morphological, molecular, and anatomical profiles of LAMP5-positive interneurons compared to other neurons in entorhinal cortex layer 1...