Project Grant R01AG102612
- The National Institute on Aging awarded the University of Washington $1,212,446 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal analysis of multi-omics biomarkers and their association with cognitive decline and dementia. The recipient will leverage serial multi-omics data with deep phenotyping to map mechanisms of cognitive decline and dementia and nominate druggable targets. The work uses two discovery and replication cohorts: the Cardiovascular...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Washington a Project Grant of $3.08 million under the Aging Research program (CFDA 93.866) beginning September 1, 2025, and concluding August 31, 2029. This grant supports the development of statistical machine learning methods to create connectome-based biomarkers for the early detection of Alzheimer's disease and related dementias (ADRD). The project addresses a critical gap in current diagnostic...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded the University of Pittsburgh $619,577 on September 1, 2026, under the Aging Research program (CFDA 93.866) for statistical methods development in spatial proteogenomics data analysis applied to Alzheimer's disease research. The project develops computational and statistical methods to advance spatial proteogenomics analysis, which integrates spatially resolved protein and transcript information to examine cellular organization in brain tissue. In Aim 1,...
- The National Institute on Aging awarded the University of Southern California $359,735 on September 1, 2026, under the Aging Research program (CFDA 93.866) for a Project Grant (R21AG091332) to develop generative artificial intelligence methods for interpretable Alzheimer's disease detection using denoising diffusion probabilistic models applied to neuroimaging. The project addresses the challenge of distinguishing brain changes attributable to Alzheimer's disease from normal age-related...
- The National Institute on Aging awarded The Washington University $642,991 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic drivers of phenotypic variability in autosomal dominant Alzheimer's disease using a multi-omics approach. The research identifies genetic alterations associated with Alzheimer's disease risk and presentation in individuals carrying mutations in the PSEN1, APP, and PSEN2 genes. The project characterizes transcriptomic brain profiles...
- The National Institute on Aging, part of the National Institutes of Health, awarded $1,250,191 to the University of North Carolina at Chapel Hill on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence and experimental workflow for accelerating discovery of small-molecule modulators that influence Alzheimer's disease through microglial phagocytosis regulation. The funded work combines AI-driven computational methods with...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Pittsburgh $2,003,400 on September 15, 2025, under the Aging Research program (CFDA 93.866) to characterize white matter injury in Alzheimer's disease. The research investigates risk factors for and consequences of white matter injury in brain regions affected by Alzheimer's pathology using a novel, spatially precise measurement method called unhealthy...
The National Institute on Aging awarded the University of Washington $575,342 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical and artificial intelligence tools that elucidate cognitive resilience in Alzheimer's disease by linking region-resolved neuropathology with cell-type programs, particularly microglia function. The project integrates quantitative digital neuropathology with single-cell and spatial molecular profiles to build methods that estimate cell-state programs co-varying with global and region-specific pathological burdens of tau, amyloid-beta, TDP-43, and alpha-synuclein; define donor-level resilience as better-than-expected cognition given pathology and demographics using region-specific burdens; and pinpoint protective states and gene programs via causal mediation across co-pathologies. The work develops novel deep-learning architectures treating brain regions as a continuum to disentangle gene expression relationships with global versus local burden, employs semi-supervised inference to transfer signal between SEA-AD and ROSMAP cohorts for higher power and generalizability, and performs principled causal mediation with uncertainty accounted for during cohort transfer. Expected outcomes include validated resilience measures leveraging region-specific neuropathological burdens, interpretable maps connecting microglial states and gene modules to protection or vulnerability in specific brain regions, and open-source methods and resources for the community. Performance occurs in Seattle, Washington. The project period runs from September 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $575.3k | 8/25/26 |