Project Grant R01AG093802
- The National Institute on Aging awarded the University of Pittsburgh $619,577 on September 1, 2026, under the Aging Research program (CFDA 93.866) for statistical methods development in spatial proteogenomics data analysis applied to Alzheimer's disease research. The project develops computational and statistical methods to advance spatial proteogenomics analysis, which integrates spatially resolved protein and transcript information to examine cellular organization in brain tissue. In Aim 1,...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Pittsburgh $2,003,400 on September 15, 2025, under the Aging Research program (CFDA 93.866) to characterize white matter injury in Alzheimer's disease. The research investigates risk factors for and consequences of white matter injury in brain regions affected by Alzheimer's pathology using a novel, spatially precise measurement method called unhealthy...
- The National Institute on Aging awarded Purdue University $387,183 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop mass spectrometry-based proteomics strategies examining post-translational modifications related to protein aggregation and extracellular vesicle-mediated propagation in neurodegenerative disease, with emphasis on Alzheimer's disease. The recipient will establish a novel proteomics platform to profile N-terminal acetylation landscapes in primary...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of Utah $437,252 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a plasma biomarker for TDP-43 proteinopathy in Alzheimer's disease and frontotemporal lobar degeneration. The project investigates MAB No. 9, a monoclonal antibody identified through screening over 5,000 antibody candidates that recognizes novel TDP-43 pathology in both diseases. Researchers will examine how MAB No. 9-positive TDP-43...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded the University of Pittsburgh $424,913 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize LAMP5 interneurons in the human entorhinal cortex and their vulnerability to tau-related Alzheimer's disease neuropathology across the aging lifespan. This R21 exploratory grant funds investigation of the morphological, molecular, and anatomical profiles of LAMP5-positive interneurons compared to other neurons in entorhinal cortex layer 1...
- The National Institute on Aging awarded Georgetown University $156,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate mitigation strategies for network dysfunction in Alzheimer's disease pathology. The project tests whether mild hyperpolarization can stabilize hippocampal network activity despite amyloid-beta-related impairment of excitatory amino acid transporters. The research quantifies sharp wave-ripples in ex vivo hippocampal slices from 5XFAD transgenic...
The National Institute on Aging awarded the University of Pittsburgh $673,702 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research deciphering ubiquilin-mediated proteostasis mechanisms in Alzheimer's disease and related dementias. The research addresses knowledge gaps in ubiquilin function and protein homeostasis defects underlying neurodegenerative disease. The project will elucidate how STI1 domain binding and E3 ligase recruitment affect cellular fitness and ADRD protein stability, phase separation, and function through a combination of structure/function studies and neuronal cell biology techniques. Preliminary data include the first crystal structure of the STI1 domain bound to a substrate, in vitro assays linking ubiquitination and phase separation to substrate protection from degradation, and cellular data demonstrating that ubiquilin protects substrates from proteasomal degradation in correlation with E3 ligase recruitment and condensate formation. Work is performed at the University of Pittsburgh in Pittsburgh, Pennsylvania, with a period of performance extending from September 1, 2026, through May 31, 2031. The award is classified as a Project Grant, a standard assistance type for investigator-initiated biomedical research under the National Institute on Aging's mission to support research on preventing and treating Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $673.7k | 8/28/26 |