Project Grant R01AG097804
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. received a $321,990 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on August 15, 2025, with completion scheduled for April 30, 2027. This award supports research aimed at establishing a foundation for integrating treatment burden assessment into primary care for older adults with multiple chronic conditions (MCCs). The project addresses a critical gap in clinical...
- Federal Grant Award Summary Brigham & Women's Hospital received a $3.69 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with a completion date of September 14, 2029. The award funds development of specialized large language models (LLMs) designed to extract Alzheimer's disease and related dementias (ADRD)-relevant clinical phenotypes from electronic health records (EHRs). The project addresses a critical...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Beth Israel Deaconess Medical Center $191,193 on September 9, 2025, under the Aging Research program (CFDA 93.866) to develop and pilot test an Electronic Health Record (EHR)-based Serious Illness Communication intervention for older adults in emergency departments (SIC-ED). Under the direction of Principal Investigator Dr. Adrian Haimovich, the project will create an EHR-embedded, transdisciplinary intervention...
- Federal Project Grant Summary The Broad Institute of MIT and Harvard received a $1.22 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion scheduled for May 31, 2030. This award supports research on the genetic dissection of mitonuclear interactions in aging and neurodegenerative disease, specifically investigating how interactions between mitochondrial DNA (mtDNA) and nuclear genome-encoded...
- Federal Project Grant Award Summary Harvard Medical School received a $251,802 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 15, 2025, with completion targeted for May 31, 2027. This award supports research investigating cell-type-specific dysregulation and genetic control of alternative polyadenylation (APA) in neurodegenerative diseases, specifically Alzheimer's disease and Parkinson's disease. The research will leverage...
- Federal Grant Award Summary Boston University Medical Campus received a $327,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 5, 2025, with completion scheduled for August 31, 2027. The grant supports research exploring heterogeneity of cognitive trajectories in preclinical Alzheimer's disease through digital phenotyping methodologies. The project leverages multimodal data integration, combining traditional...
- Federal Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $3.28 million Project Grant to Harvard T.H. Chan School of Public Health on September 15, 2025, with completion targeted for August 31, 2029. This research initiative addresses the interplay between herpesvirus infection, immune responses, apolipoprotein E (APOE) genotype, and tau-pathology development in Alzheimer's disease (AD). The primary deliverable is scientific...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant of $1,672,296 under the Aging Research program (CFDA 93.866) to conduct genetic mapping research on RNA modifications in the aging human brain and their relationship to Alzheimer's disease (AD). The project, spanning from September 1, 2025, through May 31, 2030, will deliver three primary research products: (1) a comprehensive atlas of...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $790,288 under the Aging Research program (CFDA 93.866), effective February 15, 2026, through November 30, 2030. The primary deliverable is foundational genetic research aimed at identifying disease-driving genetic variants within the MAPT locus on chromosome 17q21.31, a region associated with Alzheimer's disease and related dementias as well as multiple other...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $493,972 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. The grant supports a five-year research initiative titled "Cell Type-Specific Epitranscriptomic Regulation in the Brain in Aging and Alzheimer's Disease," which will be conducted at Duke's Durham, North Carolina research facilities....
Beth Israel Deaconess Medical Center, Inc. (BIDMC) received a $761,496 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 15, 2026, with completion scheduled for February 28, 2031. The grant supports research investigating the role of epigenetics—specifically DNA methylation patterns—in identifying individuals with a "vulnerable brain" predisposed to delirium, cognitive decline, and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) following acute stressors such as major surgery. The research deliverables include: (1) examination of epigenetic risk factors that regulate gene expression and are influenced by acute and chronic stressors; (2) development of polyepigenetic risk scores specific to delirium and delirium with cognitive decline; and (3) analysis of how social determinants of health mediate the associations between epigenetic risk and adverse neurological outcomes. The study leverages resources from three NIA-funded projects and addresses a critical gap in understanding the shared pathophysiology linking delirium and AD/ADRD, moving beyond genetic predisposition to explore epigenetic mechanisms that influence brain vulnerability in aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $761.5k | 6/8/26 |