Project Grant R01AG097607
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $804,450 (awarded June 1, 2025, with completion targeted for March 31, 2030) under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the molecular mechanisms underlying Apolipoprotein E4 (APOE4)-driven pathogenesis in Alzheimer's disease (AD). The research will focus on targeting the growth factor protein NELL2 (Neural...
- Federal Grant Award Summary The J. David Gladstone Institutes received a $630,496 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. The award funds research investigating proteostasis dysfunction, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD) caused by GRN (granulin) haploinsufficiency. The research will examine how GRN deficiency impairs the autophagy/lysosomal...
- Summary of Federal Grant Award The National Institute on Aging (NIA) awarded J. David Gladstone Institutes $801,193 under the Aging Research program (CFDA 93.866) on February 15, 2026, to support a five-year research project extending through January 31, 2031. The primary deliverable is a comprehensive scientific investigation into how the APOE4 allele disrupts energy metabolism in the context of Alzheimer's disease (AD). The research aims to identify the cellular and molecular mechanisms by...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $1,459,072 Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to investigate inhibitory neuron dysfunction in Alzheimer's disease (AD). The research will develop and implement innovative methodologies to monitor and manipulate two distinct inhibitory interneuron cell populations—parvalbumin (PVALB) and somatostatin (SST) cells—in both wildtype and AD-knock-in...
- Federal Grant Award Summary J. David Gladstone Institutes received a Project Grant award of $817,357 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with a completion date of March 31, 2030. The award supports research applying novel machine learning (ML) approaches to behavioral analysis and brain signal integration in humanized Alzheimer's disease (AD) models. The primary deliverable involves validation and development of a...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $793,777 on June 17, 2025, under the Aging Research program (CFDA 93.866) to conduct research on mitochondrial deoxyribonucleic acid (DNA) compaction and the accumulation of mutations with age and stress. The primary deliverable is a comprehensive scientific investigation utilizing innovative long-read sequencing approaches to quantify DNA accessibility, mutations, and...
- Federal Grant Award Summary The National Institute on Aging awarded a $610,836 Project Grant to the Broad Institute of MIT and Harvard (effective September 1, 2025, through May 31, 2030) under the Aging Research program (CFDA 93.866) to conduct systematic genetic research on mitonuclear interactions in aging and neurodegenerative diseases. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale analysis of mtDNA copy...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $852,273 to The Trustees of Columbia University in the City of New York, Health Sciences Division, through the Aging Research program (CFDA 93.866) on September 1, 2025, for a project extending through May 31, 2030. This Project Grant funds a comprehensive genetic mapping study investigating the role of RNA modifications—specifically N6-methyladenosine (M6A) and pseudouridine (Ps)—in Alzheimer's disease (AD) pathogenesis...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $680,792 to The Regents of the University of California, San Francisco under the Aging Research program (CFDA 93.866) effective February 1, 2026, through December 31, 2030. This project grant funds research to develop and optimize a CRISPR/Cas9 genome editing strategy targeting mutations in the MAPT gene to treat frontotemporal dementia with tau pathology (FTD-tau), a fatal and incurable condition representing...
- Federal Project Grant Award Summary The National Institute on Aging (part of the National Institutes of Health) awarded The Leland Stanford Junior University a $1,176,501 Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to develop innovative tools for dissecting the genetic etiology of Alzheimer's disease. The primary deliverable is COMBO-SEQ/TAG, a comprehensive toolkit that combines two complementary technologies: COMBO-SEQ for precisely installing multiple...
The National Institute on Aging awarded J. David Gladstone Institutes a Project Grant of $790,288 (awarded February 15, 2026, with completion by November 30, 2030) under the Aging Research program (CFDA 93.866) to conduct genetic research on the 17q21.31 MAPT locus associated with Alzheimer's disease and related dementias. The primary deliverable is a comprehensive genetic dissection study utilizing statistical genetics and machine learning methodologies to identify disease drivers within this highly complex chromosomal region. Specifically, the research will investigate the role of the microtubule-associated protein tau (MAPT) gene and other genes within the locus, clarify how genetic variants and chromosomal inversions influence disease susceptibility, and determine why certain neurodegenerative diseases associate with distinct haplotypes (H1 and H2) at this locus. The research will produce scientific findings addressing fundamental questions about the genetic mechanisms underlying multiple age-related neurodegenerative diseases, with potential applications for understanding disease pathogenesis and informing therapeutic development. As a non-profit biomedical research institution, Gladstone Institutes will deliver research outputs consistent with the National Institute on Aging's mission to advance understanding of aging processes and develop prevention and treatment strategies for Alzheimer's disease and related dementias through molecular, cellular, and genetic investigation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $790.3k | 2/6/26 |