Project Grant R01AG093664
- This federal Project Grant award of $509,413.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct research on the role of epitranscriptomic regulation of microglial cells in the development and progression of Alzheimer's disease (AD). The project will investigate how methylation of adenosine residues in mRNA (m6A modification) and its regulatory proteins are altered in the brains of AD patients, and how these changes impact microglial function and the brain's...
- This Project Grant award of $1,696,572.00, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will support a comprehensive study to map the brain's N6-methyladenosine (M6A) methylome and investigate its role in the pathogenesis of Alzheimer's disease (AD). The key objectives are to: 1) create a high-resolution reference map of M6A sites in the brains of older adults, 2) identify specific M6A alterations associated with AD and its clinical/pathological characteristics,...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- This $852,273 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of Columbia University in the City of New York, Health Sciences Division, aims to investigate the role of RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a comprehensive atlas of N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications in human brain cells from multiple ancestries and map their quantitative trait loci; 2) Integrate these...
- This federal Project Grant award of $805,573 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project to investigate the impact of m6A RNA modifications in Alzheimer's disease and related tauopathies. The award was granted to the Regents of the University of California, San Francisco and runs from September 15, 2025 through June 30, 2030. The research aims to uncover specific RNA sites with differential m6A modifications in Alzheimer's and other...
- This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate how Alzheimer's disease (AD)-associated regulatory elements orchestrate gene expression at the single-cell level. The University of North Carolina at Chapel Hill will develop and apply a scalable platform, Single-Cell Massively Parallel Reporter Assays (SCMPRA), to examine the regulatory effects of thousands of AD-associated cis-regulatory elements...
- This Project Grant award of $848,993.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to study tRNA modifications in Alzheimer's disease and related dementias (ADRD). The project, conducted by Trustees of Boston University Medical Campus, aims to examine tRNA modifications and their impact on protein translation and misfolding in ADRD. Key research activities include investigating tRNA modification changes in an ADRD mouse...
- This Project Grant award of $423,994 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University aims to characterize spatial variations in RNA isoform expression in relation to Alzheimer's disease (AD) pathology. The research will leverage single-nucleus cDNA, long-read RNA sequencing, and in situ sequencing to profile isoform expression at single-cell resolution in the inferior frontal gyrus, a brain region pertinent to AD. The study will identify cell-type...
- This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
- This $1,249,147 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will enable Epicypher, Inc., a biotechnology company in Durham, North Carolina, to develop the "AgingPTMTM" platform for studying aging-associated combinatorial histone post-translational modifications (acPTMs) in tissue. The goal is to identify novel therapeutic targets and biomarkers for aging, Alzheimer's disease, and related dementias, which are associated with chromatin...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $493,972.00 to Duke University to conduct research on the role of epitranscriptomic regulation, specifically mRNA methylation (m6A), in brain aging and Alzheimer's disease. The research aims to determine how age-dependent differential methylation of mRNAs in the brain influences the expression of Alzheimer's-associated genes, and to identify the m6A "reader" proteins that mediate these changes. The project will leverage Duke University's expertise in neuroscience, molecular biology, and bioinformatics to advance the understanding of how epitranscriptomic mechanisms contribute to brain aging and the development of Alzheimer's disease. The award has a project period from January 1, 2026 to December 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $494.0k | 12/26/25 |