Project Grant R01AG096729
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded The Leland Stanford Junior University $423,500 on April 1, 2026, under the Aging Research program (CFDA 93.866) to investigate dynamic brain circuit mechanisms associated with apathy and disinhibition in individuals with Alzheimer's disease and related dementias. The project addresses neuropsychiatric symptoms that affect nearly 80 percent of individuals with dementia, particularly apathy and disinhibition linked to deficits in motivation and cognitive...
- The National Institute on Aging awarded The Leland Stanford Junior University $646,340 on June 15, 2026, under the Aging Research program (CFDA 93.866) to construct and analyze a novel individual-level database linking health trajectories of older adults to the physical, mental, and economic well-being of their family members across multiple generations, covering 1999 to 2024. The recipient will leverage U.S. Census Bureau infrastructure for linking administrative data to examine...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $122,526 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant K99NS149164). Stanford will use the funding to delineate Alzheimer's disease initiation and propagation using novel adult human brain organoids. The work employs...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute on Aging awarded The Leland Stanford Junior University $630,031 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an artificial intelligence-driven metabolic clock for distinguishing healthy aging from Alzheimer's disease and Alzheimer's disease-related dementias. The project uses large-scale untargeted metabolomics to identify metabolic deviations associated with cognitive decline in aging and dementia. The research tests the hypothesis...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Thomas Jefferson University $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to characterize neurodegenerative hallmarks in induced neural stem cells (iNSCs) derived from patient fibroblasts to study dsRNA-mediated inflammation in C9ORF72-associated ALS and frontotemporal dementia. The research employs a novel disease model using age-preserved iNSCs directly...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
- The National Institute on Aging awarded the Regenerative Research Foundation $428,175 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell (iPSC)-derived three-dimensional vascular microphysiological model for studying cerebral amyloid angiopathy and Alzheimer's disease-related vascular pathology. The recipient will establish a 3D model incorporating microglia and vascular endothelial cells within a microfluidic device to enable...
The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model consists of defined populations of neurons, astrocytes, and microglia that, unlike existing mouse models, reproduces TDP-43 pathology—protein aggregation and nuclear depletion observed in human disease. The research addresses dysfunctional protein homeostasis via lysosomal and autophagosomal dysfunction, a central hallmark of Alzheimer's disease and related dementias. TDP-43 pathology appears across multiple neurodegenerative conditions including amyotrophic lateral sclerosis and Alzheimer's disease. Work is performed in Palo Alto, California, with a period of performance through May 31, 2031. The Aging Research program supports biomedical and behavioral research directed toward understanding aging processes and diseases affecting aging populations, with emphasis on prevention and treatment of Alzheimer's disease and related dementias. This is a Project Grant, the standard assistance type for individual research awards under the program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $682.3k | 8/19/26 |