Project Grant R21AG101730
Award Date 9/1/26
Completion Date 8/31/28
Dollars Obligated $429K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19107, USA
Similar Awards
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging, under the Department of Health and Human Services, awarded $446,875 to the University of Pennsylvania on March 15, 2026, under the Aging Research program (CFDA 93.866) to identify short RNAs that prevent and reverse aberrant phase transitions of TAF15, an RNA-binding protein implicated in approximately 10 percent of frontotemporal dementia cases. The project, R21AG091143, funds research to develop short RNAs of 25 to 34 nucleotides that antagonize pathological...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $198,728 to The Rockefeller University on February 21, 2026, under the Aging Research program (CFDA 93.866) to identify cell type-specific RNA expression and regulatory changes in entorhinal cortex clinical samples of Alzheimer's disease. The funded work develops and applies a novel methodology called CLIP-FANS (crosslinking immunoprecipitation-fluorescence activated...
- The National Institute on Aging awarded the University of Pennsylvania $6.72 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to develop short RNA therapeutics targeting TDP-43 proteinopathy across amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, and chronic traumatic encephalopathy. The recipient will identify and characterize short oligonucleotides that engage the TDP-43 protein,...
- The National Institute of Neurological Disorders and Stroke awarded Thomas Jefferson University $195,000 on May 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to map and validate RNA G-quadruplex (GQ) structures at TDP-43-regulated cryptic exons in patient-derived neurons, and to identify and optimize small molecules that selectively bind and stabilize those structures. The research combines...
- The National Institute on Aging awarded Temple University $132,448 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate NMDAR/TRPM4 signaling and mitochondrial dysfunction in Alzheimer's disease. The project tests the functional coupling of N-methyl-D-aspartate receptors (NMDARs) and TRPM4 channels as a central mechanism of neurotoxicity in Alzheimer's disease and related dementias. Research employs induced pluripotent stem cell organoids carrying AD-causing...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Thomas Jefferson University $653,174 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the metabolic homeostasis and integrated stress response axis in C9ORF72-associated ALS and FTD. The research addresses the biochemical mechanisms linking the GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene—the most common genetic...