Project Grant R01AG096626
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded The Leland Stanford Junior University $630,031 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an artificial intelligence-driven metabolic clock for distinguishing healthy aging from Alzheimer's disease and Alzheimer's disease-related dementias. The project uses large-scale untargeted metabolomics to identify metabolic deviations associated with cognitive decline in aging and dementia. The research tests the hypothesis...
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $301,575 to the Palo Alto Veterans Institute for Research on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a two-year project grant testing the combined effectiveness of the anti-amyloid medication lecanemab and exercise training for Alzheimer's disease treatment. The recipient will use the 3XTG-AD mouse line to evaluate whether...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
The National Institute on Aging awarded The Leland Stanford Junior University $658,147 for Project Grant R01AG096626 on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into mechanisms of skeletal muscle maintenance relevant to Alzheimer's disease and Alzheimer's disease-related dementia. The research examines how mitochondrial dysfunction, particularly reverse electron transport along mitochondrial complex I, contributes to NAD+ depletion during aging. The project investigates the relationship between NAD+/NADH metabolism, reactive oxygen species generation, and age-related muscle diseases including sarcopenia and inclusion body myositis, with implications for understanding aging-related neurological disease. Work is performed in Palo Alto, California with a period of performance from September 1, 2026 through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $658.1k | 8/31/26 |