Project Grant K99AG093062
- The National Institute on Aging awarded the University of Virginia $2.877 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microglia's role in neurovascular coupling and hypertensive cerebral small vessel disease. The project will test the hypothesis that microglial dysregulation of cerebral blood flow leads to hypertensive vascular dementia and endothelial rarefaction as common pathological events with Alzheimer's disease. Aim 1 will employ laser speckle...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute of Neurological Disorders and Stroke awarded $242,250 to the University of Virginia on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds research into myeloid cell regulation of cerebrovascular tone and function, specifically investigating how microglia and perivascular macrophages maintain baseline vascular structure and blood flow in the brain and facilitate vascular responses...
- The National Institute on Aging awarded the University of Virginia $433,417 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of hippocampal perineuronal net complexity in Alzheimer's disease-associated social memory dysfunction. The research examines how disruptions in perineuronal nets—specialized extracellular matrix structures surrounding neurons in the hippocampal CA2 region—contribute to social memory deficits in Alzheimer's disease. The project...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $357,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate endothelial pannexin1-induced inflammation in Alzheimer's disease. The research tests the hypothesis that amyloid-beta upregulates cerebral endothelial pannexin1 expression, which promotes vascular dysfunction and Alzheimer's disease progression through increased neuroinflammation and...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging awarded Virginia Commonwealth University $552,883 on January 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the selective vulnerability of cholinergic neurons in Alzheimer's disease. The award is a Project Grant with performance extending through November 30, 2030, at the Richmond, Virginia campus. The funded research investigates how soluble oligomeric amyloid-beta 42 (oAB42) drives selective degeneration of basal forebrain...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging awarded the Regenerative Research Foundation $428,175 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell (iPSC)-derived three-dimensional vascular microphysiological model for studying cerebral amyloid angiopathy and Alzheimer's disease-related vascular pathology. The recipient will establish a 3D model incorporating microglia and vascular endothelial cells within a microfluidic device to enable...
The National Institute on Aging awarded the University of Virginia $131,166 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microglia-pericyte signaling in maintaining basal capillary tone in health and Alzheimer's disease. The research examines how microglia, brain-resident immune cells implicated in Alzheimer's disease pathology, regulate blood flow through capillaries by modulating pericyte function via cyclooxygenase-1 (COX1) and prostaglandin E2 (PGE2) signaling. Preliminary data demonstrate that microglia localize to capillaries, physically interact with pericytes, express higher COX1 levels than astrocytes, and that genetic knockdown of microglial COX1 reduces capillary diameter and red blood cell flux. The project investigates how PGE2, produced through the COX1 pathway, induces either vessel dilation or constriction depending on which pericyte prostaglandin receptors (EP4 or EP1) it binds. Understanding these cellular and molecular mechanisms is essential because constricted capillaries occur in Alzheimer's disease patients and animal models and represent an etiological factor in disease pathology. Performance occurs in Charlottesville, Virginia, with a period of performance from August 5, 2026, through July 31, 2028. This is a Project Grant, the assistance type for investigator-initiated research projects.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.2k | 8/4/26 |