Project Grant R01AG096492
- The National Institute on Aging awarded The University of Chicago $1,460,509 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a longitudinal study examining how environmental exposures contribute to Alzheimer's disease and related dementias among older US adults. The project, titled "Experiences, Exposures, and Alzheimer's Disease: Longitudinal Study of Olfaction, Cognition, and Metabolism in Older US Adults (NSHAP Exposome)," will enrich data collection...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $660,000 on March 15, 2026, under the Aging Research program (CFDA 93.866) to develop deep learning–based image registration and morphometric analysis tools for structural MRI-derived biomarkers in Alzheimer's disease diagnosis. The project aims to improve the sensitivity and accessibility of longitudinal morphometric metrics derived from T1-weighted structural brain MRI scans—a non-invasive...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,139,309 for a Project Grant (R01AG094755) on April 15, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop advanced high-resolution MRI methods to noninvasively track cerebrospinal fluid flow and soluble amyloid-beta diffusion through perivascular spaces in the brain. The project tests three specific aims: developing and optimizing novel MR...
- The National Institute on Aging, an agency of the Department of Health and Human Services, awarded The Trustees of The University of Pennsylvania $196,020 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct epidemiological research examining the relationship between long-term air pollution exposure and dementia risk through multimodal biomarkers. The award funds investigation of how chronic exposure to fine particulate matter (PM2.5) may increase dementia risk through...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop artificial intelligence techniques for identifying cerebral amyloid angiopathy at early disease stages using multimodal MRI sequences. The recipient will integrate accessible MRI sequences—T1-weighted, T2-weighted, T2*-weighted gradient echo, fluid-attenuated inversion recovery, and diffusion imaging—to...
- The National Institute on Aging awarded Massachusetts General Hospital (doing business as The General Hospital Corporation) $679,058 under the Aging Research program (CFDA 93.866) on July 1, 2026, to investigate whether participation in the Geriatric Emergency Department Accreditation (GEDA) program improves emergency care processes and clinical outcomes for older adults with dementia. The study combines three population-based datasets from 2022–2024 (NEDI-USA for emergency department...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,329 on August 5, 2026, under the Aging Research program (CFDA 93.866) to develop advanced artificial intelligence methods for computational laminar MRI to diagnose preclinical and prodromal Alzheimer's disease. The project will create deep learning-based segmentation models to improve the resolution of in vivo structural MRI and enable accurate segmentation of the supragranular and...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $133,215 under the Aging Research program (CFDA 93.866) on August 10, 2026, to investigate dietary amino acid and gut microbiome interactions in Alzheimer's disease pathology. The research employs multi-omics approaches and longitudinal cohort data to elucidate relationships among dietary amino acids, gut microbiota composition and function, Alzheimer's disease pathology markers, cognitive...
- The National Institute on Aging awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $3,558,232 under the Aging Research program (CFDA 93.866) on August 5, 2026, to conduct the WHIMSY-AD Study examining menopause and related midlife risk factors and their impact on later-life Alzheimer's disease pathology and cognition. The study recontacts 700 participants from the Women's Health Initiative Memory Study of Younger Women (WHIMSY), now aged 75–84 years,...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $453,750 in Project Grant funding on February 15, 2026, under the Aging Research program (CFDA 93.866). The award funds a study establishing a cohort of 100 older Chinese immigrants aged 65 and above to examine cognitive outcomes, sleep quality, and circadian function in the "zeroth generation" immigrant population—aging parents of first-generation immigrant...
The National Institute on Aging, part of the Department of Health and Human Services, awarded $674,088 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how environmental and psychosocial exposures shape Alzheimer's disease and related dementias outcomes. The project introduces a novel exposome-health outcomes framework tailored to real-world data, particularly Medicare claims. The research integrates multi-modal environmental and psychosocial data with administrative health records and applies advanced causal inference techniques accounting for diagnostic variability and systematic biases. The study analyzes a large, longitudinal cohort of Medicare beneficiaries (2012–2021), incorporating inpatient, outpatient, and prescription data linked to high-resolution environmental and social exposures. Aim 1 establishes a precision dementia cohort using electronic health records and administrative data with robust outcome definitions. Aim 2 evaluates individual effects of environmental and psychosocial exposures using causal inference methods that adjust for confounding and measurement error. Aim 3 assesses joint effects of multiple exposures and identifies key drivers of dementia outcomes across geographic and socioeconomic contexts. Aim 4 promotes transparency and reproducibility through open science practices. Place of performance is Boston, Massachusetts. The period of performance runs from September 1, 2026 through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $674.1k | 8/19/26 |