Project Grant K99AG100941
- The National Institute on Aging awarded Brigham & Womens Hospital Inc. $135,540 under Project Grant K99AG097920 on July 1, 2026, to investigate microbial aging dynamics in cognitive health through a multi-omics approach. The award falls under the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research directed toward understanding the aging process and Alzheimer's disease and related dementias. The research integrates multi-omics analysis to examine...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,329 on August 5, 2026, under the Aging Research program (CFDA 93.866) to develop advanced artificial intelligence methods for computational laminar MRI to diagnose preclinical and prodromal Alzheimer's disease. The project will create deep learning-based segmentation models to improve the resolution of in vivo structural MRI and enable accurate segmentation of the supragranular and...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $674,088 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how environmental and psychosocial exposures shape Alzheimer's disease and related dementias outcomes. The project introduces a novel exposome-health outcomes framework tailored to real-world data, particularly Medicare...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop artificial intelligence techniques for identifying cerebral amyloid angiopathy at early disease stages using multimodal MRI sequences. The recipient will integrate accessible MRI sequences—T1-weighted, T2-weighted, T2*-weighted gradient echo, fluid-attenuated inversion recovery, and diffusion imaging—to...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $269,452 under the Aging Research program (CFDA 93.866) on February 18, 2026, to conduct research on proteomic aging and frailty prediction. The project integrates large-scale genetic, multi-omic, and clinical data from the UK Biobank, Multi-Ethnic Study of Atherosclerosis (MESA), FinnGen, and All of Us (combined N=70,225) to investigate the biological underpinnings of proteomic aging and...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $660,000 on March 15, 2026, under the Aging Research program (CFDA 93.866) to develop deep learning–based image registration and morphometric analysis tools for structural MRI-derived biomarkers in Alzheimer's disease diagnosis. The project aims to improve the sensitivity and accessibility of longitudinal morphometric metrics derived from T1-weighted structural brain MRI scans—a non-invasive...
- The National Institute on Aging awarded The Medical College of Wisconsin, Inc. $645,037 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate microbial and neurovascular predictors for subtypes of prodromal Alzheimer's disease. The project examines the interactions between gut microbiota, neurovascular dysfunction, Alzheimer's disease biomarkers, and clinical progression in prodromal AD. The research tests the hypothesis that microbial agents—bacteria, viruses,...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,139,309 for a Project Grant (R01AG094755) on April 15, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop advanced high-resolution MRI methods to noninvasively track cerebrospinal fluid flow and soluble amyloid-beta diffusion through perivascular spaces in the brain. The project tests three specific aims: developing and optimizing novel MR...
- The National Institute on Aging awarded Emory University $643,613 on April 1, 2026, under the Aging Research program (CFDA 93.866) to discover glycosylation-based disease processes and identify glyco-biomarkers and targets for improving Alzheimer's disease diagnosis, prognosis, and intervention. The recipient will perform innovative research using an integrated platform of intact glycopeptide-based quantitative glycoproteomics and systems biology to elucidate brain glycoproteome alterations in...
The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $133,215 under the Aging Research program (CFDA 93.866) on August 10, 2026, to investigate dietary amino acid and gut microbiome interactions in Alzheimer's disease pathology. The research employs multi-omics approaches and longitudinal cohort data to elucidate relationships among dietary amino acids, gut microbiota composition and function, Alzheimer's disease pathology markers, cognitive function, and dementia risk in older adults. At the K99 phase, the project characterizes interrelationships between these factors. At the R00 phase, the work develops a nested case-control study within a longitudinal cohort to assess midlife Alzheimer's disease biomarker changes and their associations with late-life cognitive decline, and to identify how dietary amino acids and microbial features modulate individual differences in cognitive trajectories and confer resilience or vulnerability to Alzheimer's pathology. The project combines existing metagenomics, metatranscriptomics, and metabolomics data to uncover novel microbial strains, pathways, and genes relevant to disease mechanisms. Performance occurs in Boston, Massachusetts. The period of performance runs through May 31, 2028. This is a Project Grant, a standard assistance type under the National Institute on Aging's mission to support biomedical and behavioral research and training directed toward understanding aging processes and Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.2k | 8/4/26 |