Project Grant K01AG090621
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,329 on August 5, 2026, under the Aging Research program (CFDA 93.866) to develop advanced artificial intelligence methods for computational laminar MRI to diagnose preclinical and prodromal Alzheimer's disease. The project will create deep learning-based segmentation models to improve the resolution of in vivo structural MRI and enable accurate segmentation of the supragranular and...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $660,000 on March 15, 2026, under the Aging Research program (CFDA 93.866) to develop deep learning–based image registration and morphometric analysis tools for structural MRI-derived biomarkers in Alzheimer's disease diagnosis. The project aims to improve the sensitivity and accessibility of longitudinal morphometric metrics derived from T1-weighted structural brain MRI scans—a non-invasive...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,139,309 for a Project Grant (R01AG094755) on April 15, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop advanced high-resolution MRI methods to noninvasively track cerebrospinal fluid flow and soluble amyloid-beta diffusion through perivascular spaces in the brain. The project tests three specific aims: developing and optimizing novel MR...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $1.369 million on March 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the utility of 64Cu-fibrin-binding-probe-8 positron emission tomography for in vivo detection and quantification of pathological fibrin in brain tissue within a multi-biomarker framework over four years through December 31, 2029. The award funds a methodology grant evaluating pharmacokinetics of the...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $677,276 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct PET imaging research of alpha-synuclein pathology in neurodegenerative disease. The project will evaluate whether fibrillar alpha-synuclein burden measured with [11C]SY08 PET imaging differentiates dementia with Lewy bodies, Parkinson's disease, and multiple systems atrophy from each...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $674,088 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how environmental and psychosocial exposures shape Alzheimer's disease and related dementias outcomes. The project introduces a novel exposome-health outcomes framework tailored to real-world data, particularly Medicare...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop artificial intelligence techniques for identifying cerebral amyloid angiopathy at early disease stages using multimodal MRI sequences. The recipient will integrate accessible MRI sequences—T1-weighted, T2-weighted, T2*-weighted gradient echo, fluid-attenuated inversion recovery, and diffusion imaging—to create AI-driven markers for cerebral amyloid angiopathy, a form of cerebrovascular injury common in Alzheimer's disease and related dementias. The project will examine the utility of these early white matter injury markers in identifying risk of amyloid-related imaging abnormalities, a side effect of anti-amyloid treatments for Alzheimer's disease such as lecanemab and donanemab. Early detection of cerebral amyloid angiopathy and amyloid-related imaging abnormalities has clinical implications for patient selection, monitoring frequency, and treatment continuation decisions. The award runs from August 15, 2026, through April 30, 2031, with place of performance in Massachusetts. This is a Project Grant, the assistance type under the Aging Research program supporting biomedical and behavioral research directed toward understanding the aging process and diseases affecting older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $129.3k | 8/4/26 |