Project Grant RF1AG093765
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $674,088 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how environmental and psychosocial exposures shape Alzheimer's disease and related dementias outcomes. The project introduces a novel exposome-health outcomes framework tailored to real-world data, particularly Medicare...
- The National Institute on Aging awarded Brigham & Women's Hospital Inc. $751,786 on July 15, 2026, under the Aging Research program (CFDA 93.866) to identify genetic and plasma biomarkers that predict individual response to anti-amyloid-beta monoclonal antibody therapies for Alzheimer's disease. The project will investigate whether plasma biomarkers and microglia/astrocyte-specific polygenic Alzheimer's disease risk variants can predict amyloid-beta clearance, amyloid-related imaging...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $660,000 on March 15, 2026, under the Aging Research program (CFDA 93.866) to develop deep learning–based image registration and morphometric analysis tools for structural MRI-derived biomarkers in Alzheimer's disease diagnosis. The project aims to improve the sensitivity and accessibility of longitudinal morphometric metrics derived from T1-weighted structural brain MRI scans—a non-invasive...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop artificial intelligence techniques for identifying cerebral amyloid angiopathy at early disease stages using multimodal MRI sequences. The recipient will integrate accessible MRI sequences—T1-weighted, T2-weighted, T2*-weighted gradient echo, fluid-attenuated inversion recovery, and diffusion imaging—to...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,139,309 for a Project Grant (R01AG094755) on April 15, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop advanced high-resolution MRI methods to noninvasively track cerebrospinal fluid flow and soluble amyloid-beta diffusion through perivascular spaces in the brain. The project tests three specific aims: developing and optimizing novel MR...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $1.369 million on March 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the utility of 64Cu-fibrin-binding-probe-8 positron emission tomography for in vivo detection and quantification of pathological fibrin in brain tissue within a multi-biomarker framework over four years through December 31, 2029. The award funds a methodology grant evaluating pharmacokinetics of the...
- The National Institute on Aging awarded New York University School of Medicine $3,557,115 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological mechanisms linking menopause and cognitive decline in women. The recipient will conduct a longitudinal study mapping neurobiological changes during the menopause transition in a cohort of 120 pre- and perimenopausal women aged 40–48 using state-of-the-art neuroimaging, plasma proteomics, and clinical...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,329 on August 5, 2026, under the Aging Research program (CFDA 93.866) to develop advanced artificial intelligence methods for computational laminar MRI to diagnose preclinical and prodromal Alzheimer's disease. The project will create deep learning-based segmentation models to improve the resolution of in vivo structural MRI and enable accurate segmentation of the supragranular and...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $677,276 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct PET imaging research of alpha-synuclein pathology in neurodegenerative disease. The project will evaluate whether fibrillar alpha-synuclein burden measured with [11C]SY08 PET imaging differentiates dementia with Lewy bodies, Parkinson's disease, and multiple systems atrophy from each...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The General Hospital Corporation (Massachusetts General Hospital) $680,011 on August 1, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG094740). The award funds research into the molecular mechanisms underlying tendon pathology in a murine model of menopause. The project investigates why postmenopausal women experience accelerated tendon injury and disease compared with similarly...
The National Institute on Aging awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $3,558,232 under the Aging Research program (CFDA 93.866) on August 5, 2026, to conduct the WHIMSY-AD Study examining menopause and related midlife risk factors and their impact on later-life Alzheimer's disease pathology and cognition. The study recontacts 700 participants from the Women's Health Initiative Memory Study of Younger Women (WHIMSY), now aged 75–84 years, who provided banked plasma samples approximately 25 years ago alongside rich clinical phenotypes and longitudinal cognitive data collected in midlife. Participants will undergo remote cognitive assessments and blood draws using advanced digital platforms. The research analyzes banked and prospective plasma samples for Alzheimer's disease biomarkers, including phosphorylated tau-217 (p-tau217), neurofilament light (NFL), and glial fibrillary acidic protein (GFAP). The first aim determines menopause and related midlife factors associated with later-life Alzheimer's disease plasma biomarkers. The second aim characterizes decades-long changes in Alzheimer's disease plasma biomarkers within the context of menopause and related midlife factors. The final aim examines the relationship between these midlife factors and subsequent cognitive decline. The period of performance runs through July 31, 2030. Work is performed in Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.6m | 8/3/26 |