Project Grant R21AG093037
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital $677,276 under the Aging Research program (CFDA 93.866) beginning February 15, 2026, with completion targeted for January 31, 2031. This Project Grant supports the development and clinical evaluation of positron emission tomography (PET) imaging using the novel radiotracer [11C]SY08 to detect and differentiate alpha-synuclein pathology across neurodegenerative diseases. The research aims to...
- Federal Grant Award Summary The National Institute on Aging (part of the Aging Research program, CFDA 93.866) awarded Massachusetts General Hospital a $3.17 million Project Grant on February 15, 2026, for cell therapy research aimed at treating Alzheimer's disease. The primary deliverable is the development and testing of stem cell-based therapeutic interventions to restore neuronal circuit function and cognitive impairment in Alzheimer's patients. Specifically, the research involves isolating...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $327,000 project grant under the Aging Research program (CFDA 93.866) to identify clinically relevant cognitive subtypes in preclinical Alzheimer's disease using digital phenotyping methods. The research integrates multimodal data from traditional neuropsychological testing and digital voice recordings to develop computational models that characterize heterogeneous cognitive...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $323,825 to the Trustees of Boston University (Boston University Medical Campus) under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2027. This project grant supports the development of advanced artificial intelligence (AI) tools and machine learning models designed to enhance early detection of Alzheimer's disease and related dementias (ADRD) using digital...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital $684,567 under the Aging Research program (CFDA 93.866) beginning March 1, 2026, with a completion date of December 31, 2029. This four-year methodology grant supports research evaluating the utility of 64Cu-fibrin-binding-probe-8 positron emission tomography (FBP8 PET) for detecting and quantifying pathological fibrin in the brain within a multi-biomarker framework. The primary...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.9 million Project Grant under the Aging Research program (CFDA 93.866) to develop a Multi-Organ AI-Derived Endophenotype (MAE) framework for personalized assessment of Alzheimer's disease and related dementia susceptibility. The grant, effective August 1, 2025 through July 31, 2029, supports the creation of computational diagnostic and prognostic tools by consolidating and...
- Federal Project Grant Award Summary Massachusetts General Hospital, operating under The General Hospital Corporation, received a $738,105 project grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 15, 2026, through January 31, 2031. The award funds a five-year research initiative investigating the clinical spectrum and societal impact of cognitive impairment, Alzheimer's Disease and Related Dementias (ADRDS) among people living...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $3.69M Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 15, 2025, through September 14, 2029. The award funds development of specialized Large Language Models (LLMs) designed to optimize comparative effectiveness research (CER) in Alzheimer's disease and related dementias (ADRD). The project addresses a critical gap in real-world evidence by extracting...
- Federal Grant Award Summary The National Institute on Aging awarded a $441,612 Project Grant to Boston University Medical Campus effective May 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the relationship between modifiable lifestyle risk factors and digital cognitive markers in Alzheimer's disease progression. The research leverages the Framingham Heart Study's multi-generational cohort to develop and validate digital cognitive assessment methods—including digital pen...
The National Institute on Aging (NIA) awarded Massachusetts General Hospital $660,000 under the Aging Research program (CFDA 93.866) on March 15, 2026, for a project titled "Deep Templates for Longitudinal Morphometry in Alzheimer's Disease." The three-year project, concluding February 28, 2029, aims to develop advanced neuroimaging analysis tools to improve the clinical diagnosis of Alzheimer's disease (AD) using non-invasive magnetic resonance imaging (MRI). The research addresses a critical clinical gap where misdiagnosis rates for AD exceed 15% at many medical centers relative to neuropathologic analysis, thereby improving diagnostic accuracy and clinical trial efficiency. The project will leverage deep learning and image-synthesis techniques to create anatomy-aware registration tools that enable longitudinal morphometric analysis of structural MRI scans using subject-specific templates. The deliverables include novel computational methods that generalize across different MRI scanners and hospital settings without requiring retraining or preprocessing, as well as enhanced sensitivity and accessibility of structural MRI metrics for Alzheimer's detection. By making advanced diagnostic capabilities available to hospitals with limited access to specialized biomarkers like positron emission tomography imaging, this research aims to democratize diagnostic accuracy comparable to top-performing medical institutions and support improved patient outcomes and treatment efficacy.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $660.0k | 3/12/26 |