Project Grant K23AG101527
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a $3.26 million Project Grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research investigating olfactory dysfunction as a predictor of fine particulate matter (PM2.5) exposure progression to dementia. The research initiative will operate through August 31, 2029, and will deliver scientific research products advancing understanding of how...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $107,818 to the University of Wisconsin – Madison, effective August 10, 2026, under the Aging Research program (CFDA 93.866). This one-year project investigates the effects of lifetime exposure to coal-fired power plant (CPP) emissions on Alzheimer's disease and related dementias (ADRD) neuropathology. The research will develop geospatial metrics to quantify residential proximity to CPP pollution and...
- Federal Project Grant Award Summary The University of Pennsylvania received a $429,498 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective April 15, 2026, with a completion date of March 31, 2028. The award funds development and validation of a three-dimensional Magnetic Resonance Imaging (3D MRI) method for mapping cerebral metabolic rate of oxygen (CMRO2) in the brains of dementia patients. This research addresses the gap in...
- Federal Project Grant Award Summary The University of Pittsburgh received a $667,664 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded on August 15, 2025, with completion targeted for July 31, 2027. The grant funds research investigating how inhaled environmental stressors—specifically particulate matter (PM2.5), diesel exhaust particles (DEP), and cigarette smoke—impact two key mechanisms of lung aging: mitochondrial dysfunction and cellular...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded March 15, 2026, with a completion date of February 29, 2028. This award supports research to define short ribonucleic acids (RNAs) that antagonize pathological phase transitions of TAF15 (TATA-binding associated factor 15), an RNA-binding protein implicated in frontotemporal dementia and Alzheimer's disease...
- Federal Project Grant Award Summary The University of Pennsylvania received a $486,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 5, 2025, with a completion date of May 31, 2030. This research project investigates the impact of frailty on disease relapse and therapeutic outcomes in older adults with acute myeloid leukemia (AML), with a focus on identifying biomarkers and optimizing treatment selection. The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $198,164 to the University of Pennsylvania under the Aging Research program (CFDA 93.866) effective October 29, 2025, through May 31, 2027. This Individual National Research Service Award (NRSA) provides postdoctoral research training to enable the applicant to develop expertise as an independent researcher focusing on interventions that improve outcomes and experiences for hospitalized persons living with dementia...
- Federal Grant Award Summary The University of Pennsylvania received a $613,823 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research) effective September 1, 2025, through August 31, 2030, to conduct research and development of the SENSE4SAFETY intervention. This technology-supported system addresses fall risk reduction in community-dwelling older adults aged 65 and older with mild cognitive impairment (MCI), a population experiencing falls at rates two to three times...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2.59 million Project Grant on February 15, 2026, to the University of Chicago to enhance the Pathology, Alzheimer's and Related Dementias Study (PARDOS) with a focus on understanding how environmental pollution exposure—particularly particulate matter and metals—contributes to Alzheimer's disease and related dementias (AD/ADRD) pathology across diverse ancestry populations. The grant, funded under the Aging...
- Federal Project Grant Award Summary The University of Pennsylvania received a $427,919 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 15, 2025, with completion targeted for July 31, 2027. This award supports the development of integrated micro-to-macro network models designed to advance understanding of disease spread mechanisms in Frontotemporal Dementia (FTD). The research aims to distinguish between the two primary pathologies...
The University of Pennsylvania received a $196,020 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective July 1, 2026, through March 31, 2031. This award supports an epidemiological research study investigating the biological mechanisms linking long-term air pollution exposure—specifically fine particulate matter (PM2.5)—to dementia risk. The research integrates multimodal biomarkers to elucidate whether air pollution increases dementia through Alzheimer's Disease (AD) pathology pathways (including amyloid-beta plaques and tau accumulation), cerebrovascular disease burden, neuroinflammation, or a combination thereof. The study will leverage detailed patient-level disease biology measures from two ongoing prospective cohort studies: the Penn Alzheimer's Disease Research Center cohort and the Penn Medicine Biobank cohort. The project employs novel causal inference methodology (G-computation) to examine dose-response associations between PM2.5 exposure magnitude and duration, analyzing how exposure influences plasma-based biomarkers of AD neuropathology and neuroinflammation (AB42/40, PTAU217, GFAP, and NFL) alongside neuroimaging measures of neurodegeneration and cerebrovascular disease. By establishing a mechanistic understanding of the air pollution-dementia association, this research will inform future public health interventions and clinical strategies targeting primary and secondary prevention of dementia in aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $196.0k | 7/1/26 |