Project Grant R01AG096102
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $165,348.00 to the Rector & Visitors of the University of Virginia to investigate the cellular and molecular mechanisms by which hyperphosphorylated tau protein induces neurotoxicity and cognitive deficits. The research aims to characterize the effects of hyperphosphorylated tau oligomers on brain function using transcriptomic profiling and neurophysiology approaches. Specifically, the...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $781,008.00 to investigate the role of tRNA modifications in regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome that are associated with AD status, using large-scale whole genome sequencing data from...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- This Project Grant award of $106,464 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at Brandeis University to investigate the associations among monoamine neurotransmitters, tau pathology, and emotional memory in aging. The research aims to use PET imaging techniques to directly measure monoamine synthesis capacity in the locus coeruleus and dorsal raphe nucleus, regions vulnerable to early tau pathology in Alzheimer's disease. The project will explore...
- This $1,526,066 Project Grant was awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The Leland Stanford Junior University (Stanford University). The award, with a start date of June 1, 2025 and an ultimate completion date of April 30, 2030, will fund research to investigate the shared mechanisms of tau protein toxicity across multiple neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. The...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
This Project Grant award for $472,073, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports a research project at The Trustees of Columbia University in the City of New York to investigate the role of post-translational modifications, specifically sumoylation and succinylation, in the mitochondrial-nuclear communication mechanisms underlying tau toxicity in frontotemporal dementia (FTD). The project aims to elucidate how changes in these modifications influence the mitochondrial stress response and signaling pathways in the context of FTD, with the goal of advancing scientific understanding and informing potential therapeutic approaches for this neurodegenerative disorder. The award period runs from September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/16/25 | ||
| Not listed | $472.1k | 8/28/25 |