Project Grant R01AG095060
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $577,122 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a clinical trial investigating EEG-guided analgesic titration during general anesthesia to reduce postoperative delirium in elderly surgical patients. The research tests whether maintaining alpha waves (measured via frontal electroencephalogram) during anesthesia can lower the incidence of postoperative...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded Weill Medical College of Cornell University $172,260 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize the relationship between electroencephalographic burst-suppression and postoperative delirium in the context of corticothalamic function. The recipient will investigate biomarkers for postoperative delirium, a neurocognitive disturbance...
- The National Institute on Aging awarded $1,161,596 to the University of Texas Health Science Center at Houston on August 1, 2026, under the Aging Research program (CFDA 93.866) to identify biomarkers and mechanisms underlying perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorders that increase morbidity, mortality, and long-term dementia risk. The research investigates whether non-brain-derived...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $529,744 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of entorhinal cortex hyperactivity, neuroinflammation, and tau pathology progression in Alzheimer's disease. The research will use two-photon microscopy and chemogenetic manipulation to test three central hypotheses: that entorhinal cortex layer 2 neuronal hyperactivity drives disease...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded Emory University $643,613 on April 1, 2026, under the Aging Research program (CFDA 93.866) to discover glycosylation-based disease processes and identify glyco-biomarkers and targets for improving Alzheimer's disease diagnosis, prognosis, and intervention. The recipient will perform innovative research using an integrated platform of intact glycopeptide-based quantitative glycoproteomics and systems biology to elucidate brain glycoproteome alterations in...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Vanderbilt University Medical Center $669,660 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate postsurgical pain and opioid use in older adults with mild cognitive impairment. The project will systematically evaluate the effects of mild cognitive impairment on pain processing, pain-relevant vagal inhibition, postsurgical pain experience, and opioid use...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $511,574 on July 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical methods for precision health management in high-risk Alzheimer's disease populations. The recipient will conduct three integrated research activities. Aim 1 involves evidence synthesis through semi-automated systematic review and meta-analyses of published studies to synthesize evidence on prognostic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2,957,210 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, for research extending through August 31, 2029, under the Aging Research program (CFDA 93.866). The project, titled "Deciphering the Role of CD44 Astrocytes in Alzheimer's Disease," delivers comprehensive biomedical research aimed at understanding the molecular...
The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $691,683 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the glymphatic system's role in perioperative neurocognitive disorder. The research characterizes how anesthesia and surgery impair glymphatic function—the brain's perivascular clearance pathway for neurotoxic proteins including beta-amyloid and phosphorylated tau—particularly in aging and Alzheimer's disease-vulnerable brains. The project tests the hypothesis that anesthesia and surgery exacerbate glyphatic dysfunction through a molecular cascade involving endoplasmic reticulum stress and aquaporin-4 water channel mislocalization in astrocytes, leading to impaired protein clearance and cognitive decline. The work addresses perioperative neurocognitive disorder, the most common postoperative complication in older adults, which carries increased risk for Alzheimer's disease and related dementias alongside higher morbidity, mortality, and healthcare costs. Performance is located in New York, New York with a period of performance from September 1, 2026, through May 31, 2031. The assistance type is a Project Grant. The Aging Research program supports biomedical, social, and behavioral research directed toward understanding the aging process and diseases affecting older populations, with particular emphasis on preventing and treating Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $691.7k | 8/26/26 |