Project Grant R01AG098934
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $691,683 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the glymphatic system's role in perioperative neurocognitive disorder. The research characterizes how anesthesia and surgery impair glymphatic function—the brain's perivascular clearance pathway for neurotoxic proteins including beta-amyloid and phosphorylated tau—particularly in aging and Alzheimer's...
- The National Institute on Aging awarded The Rand Corporation $1.366 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct analyses of Medicare beneficiary access to medications for opioid use disorder and assess the impacts of state and federal policies on treatment disparities and health outcomes. The research examines barriers to access for the three FDA-approved medications to treat opioid use disorder: methadone, buprenorphine, and naltrexone. The study...
- The National Institute on Aging awarded $735,047 to Vanderbilt University Medical Center on August 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a randomized controlled trial testing a perioperative geriatric intervention for older adults undergoing major cancer surgery. The award funds a multicenter hybrid implementation-effectiveness trial enrolling 354 patients at two NCI-designated cancer centers. The intervention, called PERI-OP, consists of a preoperative in-person or...
- The National Institute on Aging awarded $1,161,596 to the University of Texas Health Science Center at Houston on August 1, 2026, under the Aging Research program (CFDA 93.866) to identify biomarkers and mechanisms underlying perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorders that increase morbidity, mortality, and long-term dementia risk. The research investigates whether non-brain-derived...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded The Johns Hopkins University $597,350 on May 15, 2026, under the Aging Research program (CFDA 93.866) to develop an oral glutamate carboxypeptidase II (GCPII) inhibitor for treating peripheral nerve injury in aging populations. The project addresses age-related decline in peripheral nerve regenerative capacity by investigating GCPII inhibition as a therapeutic strategy. Preliminary data demonstrate that the prototype GCPII inhibitor 2-PMPA significantly...
- The National Institute on Aging awarded Vanderbilt University Medical Center $707,033 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate novel statistical machine learning approaches that leverage baseline neuroimaging data to increase the statistical power and cost-effectiveness of clinical trials in Alzheimer's disease and late-life depression. The project addresses the challenge of efficiently utilizing rich neuroimaging datasets collected at baseline...
- The National Institute on Aging awarded Vanderbilt University Medical Center $3,079,819 for a Project Grant (R01AG092663) on January 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research probing mechanistic links between endothelial aging and dementia. The recipient will passage human induced pluripotent stem cells differentiated to endothelial cells (hiPSC-ECs) obtained from healthy adults and individuals with vascular contributions to cognitive impairment and...
- The National Institute on Aging awarded Duke University $647,811 on September 1, 2026, under the Aging Research program (CFDA 93.866) to define the role of lipocalin-2 in postoperative delirium. The research investigates the molecular mechanisms underlying postoperative delirium, a neurologic disorder with significant morbidity, prolonged hospitalization, and increased risk of Alzheimer's disease and related dementias. The project uses a postoperative delirium mouse model to characterize how...
- The National Institute on Aging awarded Vanderbilt University Medical Center $2,129,341 on August 15, 2026, under the Aging Research program (CFDA 93.866) to conduct multiscale functional assessment of white matter across the life span. The research investigates blood oxygenation level-dependent (BOLD) signals in white matter using functional magnetic resonance imaging (fMRI) to characterize how white matter function evolves across developmental, adult, and aging stages. The project quantifies...
The National Institute on Aging, a component of the Department of Health and Human Services, awarded Vanderbilt University Medical Center $669,660 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate postsurgical pain and opioid use in older adults with mild cognitive impairment. The project will systematically evaluate the effects of mild cognitive impairment on pain processing, pain-relevant vagal inhibition, postsurgical pain experience, and opioid use throughout the perioperative period in a prospective study comparing cognitively intact patients (N=120) and patients with mild cognitive impairment (N=120) undergoing major surgery. The research will assess preoperative differences in objective pain responsiveness and clinical pain using quantitative sensory testing, measure changes from baseline in objective pain responsiveness and clinical pain postoperatively, and examine the potential role of APOE4 genetic status and plasma Aβ42/40 ratio as biomarkers for mild cognitive impairment-related differences in pain responsiveness and opioid use. The work addresses a clinical gap: more than half of the approximately 50 million major surgical procedures performed annually in the United States involve older adults, with 11 percent of these patients (approximately 3 million) having mild cognitive impairment—a condition linked to Alzheimer's disease progression—yet the impact of mild cognitive impairment on postoperative pain management and opioid-related adverse events remains unstudied. The award period runs from September 1, 2026, through June 30, 2031, with place of performance in Forest Hills, Tennessee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $669.7k | 8/21/26 |