Project Grant R01AG094916
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Vanderbilt University Medical Center $669,660 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate postsurgical pain and opioid use in older adults with mild cognitive impairment. The project will systematically evaluate the effects of mild cognitive impairment on pain processing, pain-relevant vagal inhibition, postsurgical pain experience, and opioid use...
- The National Institute on Aging awarded Vanderbilt University Medical Center $707,033 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate novel statistical machine learning approaches that leverage baseline neuroimaging data to increase the statistical power and cost-effectiveness of clinical trials in Alzheimer's disease and late-life depression. The project addresses the challenge of efficiently utilizing rich neuroimaging datasets collected at baseline...
- The National Institute on Aging awarded Vanderbilt University Medical Center $3,079,819 for a Project Grant (R01AG092663) on January 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research probing mechanistic links between endothelial aging and dementia. The recipient will passage human induced pluripotent stem cells differentiated to endothelial cells (hiPSC-ECs) obtained from healthy adults and individuals with vascular contributions to cognitive impairment and...
- The National Institute on Aging awarded the University of Rochester $635,825 under the Aging Research program (CFDA 93.866) on September 15, 2026, to evaluate the effects of a geriatric assessment oncology care model in older adults with advanced cancer by leveraging data linkages. The research links data from two major trials evaluating geriatric assessment in oncology care (NCT02107443, NCT02054741) with Centers for Medicare and Medicaid Services utilization and cost data to assess...
- The National Institute on Aging awarded Vanderbilt University $423,142 on May 1, 2026, under the Aging Research program (CFDA 93.866) to develop esophageal stents integrating wireless soft actuators for restoring peristalsis in esophageal cancer. The project, designated R21AG095751, creates a novel esophageal stent equipped with magnetically actuated undulating sheets that mimic peristaltic motion to transport liquid and solid, addressing esophageal dysmotility in esophageal cancer and other...
- The National Institute on Aging awarded Vanderbilt University $105,627 under the Aging Research program (CFDA 93.866) on August 5, 2026, to support an F30 predoctoral fellowship investigating how somatic mutations in hematopoietic stem cells contribute to aging-related diseases through clonal expansion of mutated blood cells. The research focuses on mosaic chromosomal alterations (MCAs), large-scale mutations linked to lymphoid malignancies and infection susceptibility. Aim 1 examines the...
- The National Institute on Aging awarded Vanderbilt University Medical Center $481,250 in project grant funding on February 1, 2026, under the Aging Research program (CFDA 93.866) to characterize molecular signatures and pathways that determine erythropoietin competence in renal interstitial perivascular cells and identify mechanisms underlying erythropoietin deficiency associated with chronic kidney disease. The award funds exploratory research using single-cell RNA sequencing in rat models to...
- The National Institute on Aging awarded Vanderbilt University Medical Center $610,523 on September 1, 2026, under the Aging Research program (CFDA 93.866) to examine how declines in power wheelchair vendors have affected Medicare and Medicaid beneficiary access to equipment and mobility. The study uses national Medicare and Medicaid claims data, vendor ownership records, and home health assessments to describe changes in power wheelchair vendor availability and ownership between 2007 and 2024;...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Vanderbilt University Medical Center $729,157 on September 4, 2026, under the Aging Research program (CFDA 93.866) to characterize age-specific communication and psychosocial outcomes in adults with cochlear implants across the adult lifespan. The project addresses a gap in understanding how age affects outcomes in cochlear implant recipients. Current clinical measures fail to capture the real-world...
The National Institute on Aging awarded $735,047 to Vanderbilt University Medical Center on August 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a randomized controlled trial testing a perioperative geriatric intervention for older adults undergoing major cancer surgery. The award funds a multicenter hybrid implementation-effectiveness trial enrolling 354 patients at two NCI-designated cancer centers. The intervention, called PERI-OP, consists of a preoperative in-person or telehealth consultation with a geriatrician and postoperative inpatient geriatric co-management alongside the surgical team. The trial will measure the intervention's effects on postoperative health care utilization (days alive at home as the primary outcome), surgical complications including delirium incidence, and patient-reported quality of life. The study also incorporates an effectiveness-implementation component to identify facilitators and barriers to PERI-OP adoption in clinical settings. Work is performed in Forest Hills, Tennessee, with a period of performance extending from the award date through July 31, 2031. The award is classified as a Project Grant, an assistance type supporting discrete, circumscribed research projects. Vanderbilt University Medical Center, operating as a major nonprofit academic medical center, serves as the recipient institution and primary research conductor.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $735.0k | 8/10/26 |