Project Grant R21AG093374
- Federal Project Grant Award Summary Vanderbilt University Medical Center received $1,469,914 in project grant funding from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports research titled "Probing Mechanistic Links Between Endothelial Aging and Dementia," which develops and applies a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model to investigate the...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $242,489 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 2, 2025, with a completion date of May 31, 2030. The award supports research to identify the proteomic signature associated with dual decline—the concurrent deterioration of gait and cognition in older adults—using plasma proteomics analysis and longitudinal clinical assessments. The research...
- Federal Project Grant Award Summary Vanderbilt University received a $482.8K Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research) effective February 1, 2026, through January 31, 2031, to conduct research on sphingolipid-dependent remodeling of mitochondria in aging cells. The research project will deliver scientific findings and methodological advances addressing the mechanisms by which sphingolipid accumulation contributes to age-associated mitochondrial...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $149,889 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, with completion targeted for May 31, 2030. This research initiative will develop and validate deep learning (DL) and artificial intelligence (AI) approaches to identify epigenetic factors associated with early-stage osteoporosis and osteopenia through analysis of computed...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $3.15 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion targeted for June 30, 2030. The research initiative investigates the relationship between serum psychotropic drug levels, cytochrome P450 (CYP) metabolizer status, and delirium duration in older hospitalized patients. The project employs liquid...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $750,000 project grant award effective September 1, 2025, through June 30, 2030, under the Trans-NIH Research Support program (CFDA 93.310) administered by the National Institutes of Health Office of the Director. The award supports research investigating the nexus of trained immunity and stable immune complexes with implications for aging-related conditions in people living with HIV (PLWH). The project...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $3.53 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2029. The award supports a comprehensive four-year research initiative to identify sex-specific genetic drivers of cerebrovascular disease (CVD) in Alzheimer's disease (AD) affected brains. The research team will conduct genome-wide association analyses...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Van Andel Research Institute (VAI) a $528,000 Project Grant under the Aging Research program (CFDA 93.866) for the period September 15, 2025 through August 31, 2027. The grant funds advanced scientific research on lineage-traced single-cell analysis of epigenetic clocks, a project designed to elucidate the biological mechanisms underlying age-related changes in DNA methylation profiles. The research deliverables...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received $813,284 in project grant funding from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 18, 2025, with completion targeted for May 31, 2030. The award funds a prospective clinical research study investigating acute kidney injury-associated delirium following cardiac surgery (CS-AKI-DELIRIUM) in 300 adult patients undergoing on-pump...
- Federal Grant Award Summary The National Institute on Aging awarded Duke University a $680,818 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866) to conduct the INFUSE HFPEF (Iron Needed for Function and Undesirable Symptoms in Elderly with Heart Failure with Preserved Ejection Fraction) study. This double-blind, placebo-controlled randomized clinical trial will evaluate the efficacy of intravenous iron supplementation in 300...
Vanderbilt University Medical Center received a $481,250 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for January 31, 2028. The award supports research to identify molecular signatures and markers of erythropoietin (EPO) competence in kidney cells, addressing a critical gap in understanding how chronic kidney disease and inflammation contribute to anemia in elderly populations. Using single-cell RNA sequencing in rat models, researchers will characterize molecular pathways that distinguish EPO-competent renal interstitial perivascular cells in normal kidneys versus those affected by chronic kidney injury and inflammation, with the goal of identifying and validating biomarkers that explain relative EPO deficiency associated with chronic kidney disease. This exploratory grant advances the scientific understanding of age-related anemia, a condition prevalent in elderly individuals that increases risk for adverse cardiovascular events, cognitive decline, and diminished quality of life. The research directly aligns with the National Institute on Aging's mission to support biomedical research directed toward greater understanding of the aging process and disease prevention in older populations. The work is performed at Vanderbilt University Medical Center in Forest Hills, Tennessee, leveraging the institution's established research infrastructure and scientific expertise in aging-related health challenges.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $481.3k | 1/28/26 |