Project Grant R21AG098425
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded The University of Kentucky Research Foundation $590,826 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale microgels delivering growth factors to enhance muscle outcomes in sarcopenia. The project tests injectable microgel carriers loaded with glial cell line-derived neurotrophic factor (GDNF) and agrin, both encapsulated in porous silicon nanoparticles. GDNF promotes motor neuron survival and neuromuscular...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded Auburn University $166,152 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNA-1 in regulating pyruvate metabolism in patients with peripheral artery disease. The research addresses skeletal muscle metabolic dysfunction in PAD, a condition affecting 8–12 million Americans and 10–15 percent of the population age 65. The award supports investigation of how microRNA-1, the most abundant microRNA in skeletal...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $429,000 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate endothelial senescence intervention in limb muscle ischemia using exercise mimetics. The research will measure the effect of exercise mimesis on preventing or reversing muscle decline associated with peripheral arterial disease in aging populations. The project employs unique transgenic mouse lines, including...
- The National Institute on Aging awarded Wake Forest University Health Sciences $1.31 million on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic effects of unacylated ghrelin and endurance exercise on sarcopenia and mobility loss in older adults. The research combines unacylated ghrelin (UNAG) administration with endurance exercise training to enhance mitochondrial bioenergetics and preserve neuromuscular junction integrity in aging mice....
- The National Institute on Aging awarded The Salk Institute for Biological Studies $1.359 million on February 15, 2026, under the Aging Research program (CFDA 93.866) to characterize activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determine functional consequences for sensorimotor behaviors. The research selectively perturbs activity in different classes of cutaneous afferent neurons to identify inputs that support cell survival in adult mice,...
- The National Institute on Aging awarded the University of Washington $485,375 under the Aging Research program (CFDA 93.866) on September 1, 2026 for Project Grant R21AG102427. The award funds development and expansion of naturally aged three-dimensional engineered muscle tissue (3D-EMT) models to test metabolic and contractile function in vitro as a mechanistic platform for studying sarcopenia. The research examines the contribution of extracellular factors to aged 3D-EMT function and...
The National Institute on Aging, within the Department of Health and Human Services, awarded $434,856 to the University of Nebraska Board of Regents on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNAs in sarcopenia through a novel muscle-specific mouse model. The recipient will test the hypothesis that microRNA dysregulation contributes to age-related muscle loss by pursuing two specific aims: blocking microRNA-mediated gene repression to determine whether it leads to premature sarcopenia, and identifying which microRNAs are essential for maintaining skeletal muscle fibers and the neuromuscular junction in aged muscles. Preliminary data using the controllable, reversible mouse model demonstrated that inhibiting microRNA function for only ten days in adult skeletal muscle induces gene expression patterns characteristic of an age-like phenotype. The work addresses the substantial economic burden of sarcopenia—approximately $40 billion annually in hospitalization costs in the United States—and aims to clarify molecular mechanisms underlying muscle degeneration to inform rehabilitation strategies and reduce fall and frailty risk. The award is a Project Grant with a period of performance from September 1, 2026, through August 31, 2028. Work is performed in Nebraska. The Aging Research program supports biomedical, social, and behavioral research directed toward understanding the aging process and diseases affecting older populations, with particular emphasis on Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $434.9k | 8/27/26 |