This Project Grant from the National Institutes of Health National Institute on Aging provides $4,489,362 to Duke University from September 15, 2022 through August 31, 2025 under the Aging Research program (CFDA 93.866). The grant will fund research to identify mechanisms of blood-brain barrier dysfunction in delirium superimposed on dementia after surgery. Specifically, the researchers will characterize how the postoperative systemic environment impacts the blood-brain barrier using...
Duke University has been awarded a $4,537,430 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, to support research under the Aging Research program (CFDA 93.866). The grant will fund a study from September 2022 to August 2025 to examine the role of cellular senescence on postoperative neuroinflammation. Specifically, the researchers will use a mouse model of orthopedic fracture to determine how senescent cell burden exacerbates systemic...
This $180,252 federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will support research by Dr. Michael Devinney at Duke University to examine the role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment. The award aims to advance Dr. Devinney's career development as an independent critical care physician-scientist focused on uncovering the underlying mechanisms contributing to...
This federal Project Grant award of $768,427.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a 3-year longitudinal study to determine the mechanisms linking midlife vascular risk factors with the early loss of brain tissue structure and cognitive function. The study aims to (1) investigate the early drivers of increased cerebrovascular pulsatility, (2) evaluate the spatial and temporal relationship between cerebrovascular pulsatility and brain tissue...
This federal Project Grant award of $125,373 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify genetic associations between Alzheimer's disease (AD) and cardio-cerebrovascular risk factors (CVRFs) such as hypertension and diabetes. The overarching goal is to elucidate the interplay between genes, CVRFs, and AD risk, with the potential to reveal novel molecular targets for prevention and treatment strategies tailored to diverse racial/ethnic...
This $2,557,260 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a study to investigate the early transition to Alzheimer's disease and related dementias (ADRD) among Black and White adults in their 60s. The study, led by the University of California, San Francisco (UCSF), will leverage the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) study to assess cognitive function, neurodegeneration, vascular health, and social determinants...
This Project Grant award of $834,094 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to determine the incidence and prevalence of post-stroke cognitive impairment and dementia (PSCID), identify associated risk factors, and evaluate potential pharmacological prevention strategies. The project will leverage a nationwide stroke registry and Medicare data to build a real-world data platform for PSCID research. The research aims to provide more accurate estimates...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project at the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The $640,906 grant, awarded on June 1, 2025, will leverage existing longitudinal data from over 2,000 participants to reprocess MRI data and provide a detailed spatial characterization of intracranial vascular stiffness and neurovascular flow tone...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,306,767 to Duke University to investigate the neural mechanisms underlying "attentional resilience" in older adults. The objective is to better understand how robust attentional control processes, such as alpha power modulation and sensory processing enhancement, can enable individuals to maintain cognitive performance despite physiological stressors like surgery-induced...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $148,568 to Duke University to conduct a study on the use of high-resolution diffusion imaging to examine white matter connectivity in healthy aging and Alzheimer's disease. The project aims to translate earlier work on high-resolution diffusion-weighted imaging (DWI) in rodents and younger adults to investigate how standard and high-resolution DWI measures relate to age-related...