This $1,277,367 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will fund research to investigate the early transition to Alzheimer's disease and related disorders (ADRD) among Black and White adults in their 60s. The primary objectives are to: 1) Identify the earliest manifestations of ADRD during the midlife to early late-life period, 2) Determine the underlying mechanistic pathways including neurodegenerative, vascular, and social determinants of health factors, and 3) Develop a prognostic model for ADRD risk in midlife to guide prevention strategies. This 5-year study will leverage the existing Coronary Artery Risk Development in Young Adults (CARDIA) longitudinal cohort, which includes equal representation of Black and White participants, to comprehensively examine the transition to ADRD and associated disparities. The Regents of the University of California, San Francisco (UCSF) is the primary grant recipient and will collaborate with other academic and healthcare partners as appropriate to deliver on the research aims.
Generated 3/4/25, 4:19 AM